Diffuse Midline Glioma H3 K27M-Mutant
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Diffuse Midline Glioma H3 K27M-Mutant Overview

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Learn About Diffuse Midline Glioma H3 K27M-Mutant

View Main Condition: Brain Tumor

What is the definition of Diffuse Midline Glioma H3 K27M-Mutant?
Diffuse intrinsic pontine glioma (DIPG) is a type of aggressive brain tumor that occurs in the pons, part of the brainstem. The pons is important for many bodily functions, including regulating breathing, heart rate, bladder control, balance, and more.  Diffuse intrinsic pontine glioma primarily affects children, with roughly 150-300 new diagnoses per year. 
What are the causes of Diffuse Midline Glioma H3 K27M-Mutant?
The cause of diffuse intrinsic pontine glioma is not currently known. Research is being done to identify if certain genetic mutations may be causing DIPG. 
What are the symptoms of Diffuse Midline Glioma H3 K27M-Mutant?
Symptoms of diffuse intrinsic pontine glioma often develop quickly. Symptoms may include poor coordination, arm and leg weakness, as well as difficulty controlling eye movements and facial expressions. Some individuals may experience difficulty speaking or eating as well. 
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What are the current treatments for Diffuse Midline Glioma H3 K27M-Mutant?
The main treatments for diffuse intrinsic pontine glioma currently include radiation therapy and experimental chemotherapy.  Radiation therapy is generally used for newly diagnosed DIPG. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Various clinical trials have shown that routine chemotherapy is not effective for treating DIPG. Newer treatments combine chemotherapy with biologic therapy that directly target the tumor.  Because of the tumor's location in the brainstem, it is rarely possible to perform surgery without risk of causing neurological damage. 
Who are the top Diffuse Midline Glioma H3 K27M-Mutant Local Doctors?
Distinguished in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Nalin Gupta
Neurosurgery
Distinguished in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Nalin Gupta
Neurosurgery
Referral may be required

Fetal Treatment Center

1855 Fourth St., Second Floor, Room A-2432, 
San Francisco, CA 
800-793-3887
Languages Spoken:
English
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Accepting New Patients

Nalin Gupta is a Neurosurgery provider practicing medicine in San Francisco, California. Dr. Gupta is rated as a Distinguished provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. He is also highly rated in 22 other conditions, according to our data. His clinical expertise encompasses Glioma, Gliomatosis Cerebri, Brain Tumor, Osteotomy, and Craniectomy. Dr. Gupta is board certified in American Board Of Neurological Surgery, Neurological Surgery. Dr. Gupta is currently accepting new patients.

Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Mark M. Souweidane
Neurosurgery | Pediatrics
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Mark M. Souweidane
Neurosurgery | Pediatrics
Referral may be required

Weill Cornell Medicine Brain & Spine Center

1305 York Ave, 9th Floor, 
New York, NY 
212-746-2363
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Mark Souweidane is a Pediatrics specialist and a Neurosurgery provider practicing medicine in New York, New York. Dr. Souweidane is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Diffuse Midline Glioma H3 K27M-Mutant, Brain Tumor, Gliomatosis Cerebri, Medulloblastoma, and Osteotomy. Dr. Souweidane is board certified in American Board Of Pediatric Neurological Surgery and American Board Of Neurological Surgery. Dr. Souweidane is currently accepting new patients.

 
 
 
 
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Elite in Diffuse Midline Glioma H3 K27M-Mutant
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Referral may be required

Facial Reconstructive Surgical And Medical Center

750 Welch Rd Ste 317, 
Palo Alto, CA 
650-497-8953
Languages Spoken:
English
See accepted insurances

Michelle Monje is a Neurologist practicing medicine in Palo Alto, California. Dr. Monje is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. She is also highly rated in 13 other conditions, according to our data. Her clinical expertise encompasses Diffuse Midline Glioma H3 K27M-Mutant, Glioma, Brain Stem Cancer, and Gliomatosis Cerebri.

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What is the outlook (prognosis) for Diffuse Midline Glioma H3 K27M-Mutant?
The prognosis for diffuse intrinsic pontine glioma is very poor. Although there is no cure, a small percentage of patients survive.
What are the latest Diffuse Midline Glioma H3 K27M-Mutant Clinical Trials?
A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
Who is this study for: Patients with Malignant Glioma, Anaplastic Astrocytoma
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Drug, Procedure, Radiation
Study Drug: Selinexor
Study Phase: Phase 1/Phase 2

Summary: This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. It also tests whether combination of selinexor and standard radiation therapy works to shrink...

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Molecularly-Guided Phase II Umbrella Trial for Children, Adolescents, and Young Adults Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma
Molecularly-Guided Phase II Umbrella Trial for Children, Adolescents, and Young Adults Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma
Enrollment Status: Recruiting
Publish Date: September 08, 2026

Summary: The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular profiling will decide if patients are eligible to participate in a subsequent treatment-based clinical trial based on the genetic alterations identified in their tumor.

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What are some Advocacy Organizations?
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Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.