Diffuse Midline Glioma H3 K27M-Mutant
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Learn About Diffuse Midline Glioma H3 K27M-Mutant

View Main Condition: Brain Tumor

What is the definition of Diffuse Midline Glioma H3 K27M-Mutant?
Diffuse intrinsic pontine glioma (DIPG) is a type of aggressive brain tumor that occurs in the pons, part of the brainstem. The pons is important for many bodily functions, including regulating breathing, heart rate, bladder control, balance, and more.  Diffuse intrinsic pontine glioma primarily affects children, with roughly 150-300 new diagnoses per year. 
What are the causes of Diffuse Midline Glioma H3 K27M-Mutant?
The cause of diffuse intrinsic pontine glioma is not currently known. Research is being done to identify if certain genetic mutations may be causing DIPG. 
What are the symptoms of Diffuse Midline Glioma H3 K27M-Mutant?
Symptoms of diffuse intrinsic pontine glioma often develop quickly. Symptoms may include poor coordination, arm and leg weakness, as well as difficulty controlling eye movements and facial expressions. Some individuals may experience difficulty speaking or eating as well. 
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What are the current treatments for Diffuse Midline Glioma H3 K27M-Mutant?
The main treatments for diffuse intrinsic pontine glioma currently include radiation therapy and experimental chemotherapy.  Radiation therapy is generally used for newly diagnosed DIPG. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Various clinical trials have shown that routine chemotherapy is not effective for treating DIPG. Newer treatments combine chemotherapy with biologic therapy that directly target the tumor.  Because of the tumor's location in the brainstem, it is rarely possible to perform surgery without risk of causing neurological damage. 
Who are the top Diffuse Midline Glioma H3 K27M-Mutant Local Doctors?
Eric Raabe
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Oncology | Pediatrics
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Oncology | Pediatrics

Johns Hopkins Children's Center

Baltimore, MD 
Languages Spoken:
English, French

Eric Raabe, M.D., Ph.D., is an associate professor of oncology and pathology at Johns Hopkins School of Medicine. Dr. Raabe majored in neural science at Brown University and received his M.D. and Ph.D. from the University of Cincinnati College of Medicine. He completed his pediatric internship and residency at Children’s Hospital of Philadelphia. After spending a year working in Africa as part of the Baylor International Pediatric AIDS Initiative, Dr. Raabe joined Johns Hopkins as a pediatric oncology fellow. Working in the laboratory of Charles Eberhart in Neuropathology, Dr. Raabe established a neural stem cell system to create genetically accurate models of pediatric brain tumors. In collaboration with patients and families, he has also developed multiple pediatric brain tumor cell lines that are some of the key models used for pre-clinical testing. Dr. Raabe sees patients in the pediatric oncology outpatient clinic at Johns Hopkins, with a focus on pediatric brain tumors. Dr. Raabe is also the point person in oncology for retinoblastoma care. He continues his research in the new Smith Building of the Wilmer Eye Institute in the Neuropathology Division, in collaboration with Charles Eberhart. Dr. Raabe is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Rhabdoid Tumor, Diffuse Midline Glioma H3 K27M-Mutant, Glioma, and Medulloblastoma.

Elite in Diffuse Midline Glioma H3 K27M-Mutant
Hematology | Oncology
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Hematology | Oncology

Dana-Farber Cancer Institute

450 Brookline Ave, 
Boston, MA 
Languages Spoken:
English

Katherine Warren is a Hematologist and an Oncologist in Boston, Massachusetts. Dr. Warren is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. Her top areas of expertise are Diffuse Midline Glioma H3 K27M-Mutant, Brain Stem Cancer, Glioma, and Medulloblastoma.

 
 
 
 
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Elite in Diffuse Midline Glioma H3 K27M-Mutant
Hematology | Oncology
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Hematology | Oncology

SJCRH Physician

262 Danny Thomas Pl # 515, 
Memphis, TN 
Languages Spoken:
English

Alberto Broniscer is a Hematologist and an Oncologist in Memphis, Tennessee. Dr. Broniscer is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Diffuse Midline Glioma H3 K27M-Mutant, Brain Stem Cancer, Glioma, and Medulloblastoma.

What is the outlook (prognosis) for Diffuse Midline Glioma H3 K27M-Mutant?
The prognosis for diffuse intrinsic pontine glioma is very poor. Although there is no cure, a small percentage of patients survive.
What are the latest Diffuse Midline Glioma H3 K27M-Mutant Clinical Trials?
A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)

Summary: This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. It also tests whether combination of selinexor and standard radiation therapy works to shrink...

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Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

Summary: The BIOMEDE 2.0 study is the second stage of the BIOMEDE multi-arm, multistage rolling programme (adaptive platform protocol). It is a multicenter, randomized, open-label, controlled phase-3 trial evaluating efficacy of ONC201 in comparison with everolimus (primary objective based on internal comparison) and subsequently to historical controls. Two treatment groups will be compared. A switch betwe...

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Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.