Diffuse Midline Glioma H3 K27M-Mutant Overview

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Learn About Diffuse Midline Glioma H3 K27M-Mutant

View Main Condition: Brain Tumor

What is the definition of Diffuse Midline Glioma H3 K27M-Mutant?
Diffuse intrinsic pontine glioma (DIPG) is a type of aggressive brain tumor that occurs in the pons, part of the brainstem. The pons is important for many bodily functions, including regulating breathing, heart rate, bladder control, balance, and more.  Diffuse intrinsic pontine glioma primarily affects children, with roughly 150-300 new diagnoses per year. 
What are the causes of Diffuse Midline Glioma H3 K27M-Mutant?
The cause of diffuse intrinsic pontine glioma is not currently known. Research is being done to identify if certain genetic mutations may be causing DIPG. 
What are the symptoms of Diffuse Midline Glioma H3 K27M-Mutant?
Symptoms of diffuse intrinsic pontine glioma often develop quickly. Symptoms may include poor coordination, arm and leg weakness, as well as difficulty controlling eye movements and facial expressions. Some individuals may experience difficulty speaking or eating as well. 
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What are the current treatments for Diffuse Midline Glioma H3 K27M-Mutant?
The main treatments for diffuse intrinsic pontine glioma currently include radiation therapy and experimental chemotherapy.  Radiation therapy is generally used for newly diagnosed DIPG. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Various clinical trials have shown that routine chemotherapy is not effective for treating DIPG. Newer treatments combine chemotherapy with biologic therapy that directly target the tumor.  Because of the tumor's location in the brainstem, it is rarely possible to perform surgery without risk of causing neurological damage. 
Who are the top Diffuse Midline Glioma H3 K27M-Mutant Local Doctors?
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Alberto Broniscer
Pediatric Hematology Oncology
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Alberto Broniscer
Pediatric Hematology Oncology
262 Danny Thomas Place, Ms 0515, St. Jude Children's Research Hospital, 
Memphis, TN 
901-595-3006
Languages Spoken:
English
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Alberto Broniscer is a Pediatric Hematologist Oncology provider in Memphis, Tennessee. Dr. Broniscer is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Diffuse Midline Glioma H3 K27M-Mutant, Brain Stem Cancer, Glioma, and Medulloblastoma.

Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Mark M. Souweidane
Neurosurgery | Pediatrics
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Mark M. Souweidane
Neurosurgery | Pediatrics

Weill Cornell Medicine Brain & Spine Center

1305 York Ave, 9th Floor, 
New York, NY 
212-746-2363
Languages Spoken:
English
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Mark Souweidane is a Pediatrics specialist and a Neurosurgery provider in New York, New York. Dr. Souweidane is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Diffuse Midline Glioma H3 K27M-Mutant, Brain Tumor, Gliomatosis Cerebri, Craniopharyngioma, and Osteotomy.

 
 
 
 
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Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Oren J. Becher
Pediatric Hematology Oncology
Elite in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Oren J. Becher
Pediatric Hematology Oncology
2100 Erwin Rd, 
Durham, NC 
919-684-8111
Languages Spoken:
English
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Oren Becher is a Pediatric Hematologist Oncology provider in Durham, North Carolina. Dr. Becher is rated as an Elite provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Diffuse Midline Glioma H3 K27M-Mutant, Glioma, Brain Stem Cancer, and Medulloblastoma.

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What is the outlook (prognosis) for Diffuse Midline Glioma H3 K27M-Mutant?
The prognosis for diffuse intrinsic pontine glioma is very poor. Although there is no cure, a small percentage of patients survive.
What are the latest Diffuse Midline Glioma H3 K27M-Mutant Clinical Trials?
A Combination Therapy Trial Using an Adaptive Platform Design for Children and Young Adults With Diffuse Midline Gliomas (DMGs) Including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression
A Combination Therapy Trial Using an Adaptive Platform Design for Children and Young Adults With Diffuse Midline Gliomas (DMGs) Including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression
Who is this study for: Patients with Malignant Glioma
Enrollment Status: Recruiting
Publish Date: December 17, 2025
Intervention Type: Drug, Radiation
Study Drugs: ONC201, Paxalisib
Study Phase: Phase 2

Summary: This phase II trial determines if the combination of ONC201 with different drugs is effective for treating participants with diffuse midline gliomas (DMGs). Despite years of research, little to no progress has been made to improve outcomes for participants with DMGs, and there are few treatment options. This trial will utilize an adaptive platform design in that the different treatment arms for ea...

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A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
Who is this study for: Patients with Malignant Glioma, Anaplastic Astrocytoma
Enrollment Status: Recruiting
Publish Date: December 17, 2025
Intervention Type: Drug, Procedure, Radiation
Study Drug: Selinexor
Study Phase: Phase 1/Phase 2

Summary: This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. It also tests whether combination of selinexor and standard radiation therapy works to shrink...

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What are some Advocacy Organizations?
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Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.