• Signed Informed Consent Form

• ≥ 1 year of age

• Disease status

‣ Patients must have high-risk neuroblastoma according to Children's Oncology Group risk classification at the time of study enrollment.

⁃ Histologically confirmed diagnosis of neuroblastoma that is recurrent/relapsed/persistent according to International Neuroblastoma Response Criteria

⁃ Patients must have evaluable or measurable disease at enrollment

• Adequate organ function

• Adequate performance status defined as Lanksy or Karnofsky performance score ≥60.

• Subjects of reproductive potential must agree to use acceptable birth control methods.