NeuroblastomaSymptoms, Doctors, Treatments, Advances & More
Learn About Neuroblastoma
View Main Condition: Neural Crest Tumor
Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.
Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes—those that control cell growth and division (proliferation) or maturation (differentiation)—allow cells to grow and divide uncontrollably to form a tumor. In most cases, these genetic changes are acquired during a person's lifetime and are called somatic mutations. Somatic mutations are present only in certain cells and are not inherited. When neuroblastoma is associated with somatic mutations, it is called sporadic neuroblastoma. It is thought that somatic mutations in at least two genes are required to cause sporadic neuroblastoma. Less commonly, gene mutations that increase the risk of developing cancer can be inherited from a parent. When the mutation associated with neuroblastoma is inherited, the condition is called familial neuroblastoma. Mutations in the ALK and PHOX2B genes have been shown to increase the risk of developing sporadic and familial neuroblastoma. It is likely that there are other genes involved in the formation of neuroblastoma.
Common conditions include: Ganglioneuroblastoma, Hereditary Neuroblastoma, Olfactory Neuroblastoma
Neuroblastoma is the most common cancer in infants younger than 1 year. It occurs in 1 in 100,000 children and is diagnosed in about 650 children each year in the United States.
Most people with neuroblastoma have sporadic neuroblastoma, meaning the condition arose from somatic mutations in the body's cells and was not inherited.
Duke Children's Health Center Hematology/Oncology Clinic
Susan Kreissman is a Pediatrics provider practicing medicine in Durham, North Carolina. She has been practicing medicine for over 41 years. Dr. Kreissman is rated as an Elite provider by MediFind in the treatment of Neuroblastoma. She is also highly rated in 9 other conditions, according to our data. Her clinical expertise encompasses Neuroblastoma, Embryonal Tumor with Multilayered Rosettes, Hepatoblastoma, Langerhans Cell Histiocytosis, and Bone Marrow Aspiration. Dr. Kreissman is board certified in American Board Of Pediatrics, Pediatric Hematology-Oncology.
Atrium Health Levine Children’s Cancer & Blood Disorders, A Facility Of Carolinas Medical Center
Javier Oesterheld is a Hematologist and an Oncologist practicing medicine in Charlotte, North Carolina. He has been practicing medicine for over 25 years. Dr. Oesterheld is rated as a Distinguished provider by MediFind in the treatment of Neuroblastoma. He is also highly rated in 5 other conditions, according to our data. His clinical expertise encompasses Neuroblastoma, Embryonal Tumor with Multilayered Rosettes, Ewing Sarcoma, Osteosarcoma, and Bone Marrow Transplant. Dr. Oesterheld is board certified in American Board Of Pediatrics, Pediatric Hematology And Oncology and American Board Of Pediatrics. Dr. Oesterheld is currently accepting new patients.
Atrium Health Levine Children’s Cancer & Blood Disorders, A Facility Of Carolinas Medical Center
Joel Kaplan is a Hematologist and a Pediatrics provider practicing medicine in Charlotte, North Carolina. He has been practicing medicine for over 25 years. Dr. Kaplan is rated as a Distinguished provider by MediFind in the treatment of Neuroblastoma. He is also highly rated in 15 other conditions, according to our data. His clinical expertise encompasses Neuroblastoma, Embryonal Tumor with Multilayered Rosettes, Medulloblastoma, Langerhans Cell Histiocytosis, and Bone Marrow Aspiration. Dr. Kaplan is board certified in American Board Of Pediatrics and American Board Of Pediatrics, Pediatric Hematology And Oncology. Dr. Kaplan is currently accepting new patients.
Summary: This is a prospective, multicenter clinical trial in subjects with newly diagnosed high-risk neuroblastoma to evaluate the efficacy and safety of administering naxitamab with standard induction therapy. The initial chemotherapy will include 5 cycles of multi-agent chemotherapy. Naxitamab will be added to all 5 Induction cycles. We hypothesize that the addition of anti-GD2 therapy to induction chem...
Summary: The purpose of this clinical trial is to assess the feasibility, safety and efficacy of multiple 4SCAR-T cell therapy which targets GD2, PSMA and CD276 surface antigens in patients with relapsed and refractory neuroblastoma (NB). Another goal of the study is to understand the function of the multi-CAR-T cells and their persistency in the patients.
Published Date: March 01, 2011
Published By: National Institutes of Health