Efficacy and Safety of Induction Chemotherapy for Olfactory Neuroblastoma: a Prospective Umbrella Clinical Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The goal of this clinical trial is to learn about the induction chemotherapy efficacy in olfactory neuroblastoma. The main question it aims to answer is: wether olfactory neuroblastoma patients with different pathology subtypes apply to different induction chemotherapy schemes. Participants will be treated with different chemotherapy schemes, to evaluate the tumor remission rate and long term survival.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with pathologically confirmed olfactory neuroblastoma;
• Age ≥ 18 years old;
• Dulguerov stage T2-T4;
• Patients who signed the informed consent forms;
• No distant metastasis.
Locations
Other Locations
China
Eye & ENT Hospital of Fudan University
RECRUITING
Shanghai
Contact Information
Primary
Xiaole Song, MD
jxfxsxl@163.com
15821388769
Backup
Jingyi Yang, MD
yangjingyi_ent@163.com
19529941927
Time Frame
Start Date: 2024-03-01
Estimated Completion Date: 2030-03-01
Participants
Target number of participants: 25
Treatments
Experimental: Induction chemotherapy in different subtypes of olfactory neuroblastoma
Induction chemotherapy based on pathological molecular subtypes of olfactory neuroblastoma.~① According to the immunohistochemical results of the pathological report, patients with Ki-67 index ≥ 25% were treated with two weeks of gemcitabine+platinum based chemotherapy regimen;~② According to the immunohistochemical results of the pathological report, patients with Ki-67 index \<25% were treated with a basic chemotherapy regimen of cyclophosphamide+etoposide+cisplatin (CEP regimen);~According to the progression of the patient's disease, the combination of other chemotherapy/small molecule drugs/targeted drugs can be considered;
Related Therapeutic Areas
Sponsors
Leads: Hongmeng Yu