3-D Tractography Focused Ultrasound Ablation for Essential Tremor
The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain. The investigators hypothesize that 3-D tractography Vim-FUSA will improve the Vim ablation compared to standard Vim-FUSA and prove safe and feasible in the clinical setting. The investigators also hypothesize that intraoperative magnetic resonance (i-MR) monitoring will differentiate ablated tissue from immediate perilesional edema and accurately predict the Vim-FUSA clinical outcomes.
• Diagnosis of moderate to severe ET agreed upon by at least two movement disorder trained physicians
• Symptoms refractory to at least two medications
• Stable essential tremor medication regimen for at least 4 weeks prior to screening
• Willing and able to participate in all follow-up visits
• Willing and able to undergo MR imaging.