Ultrasound Neuromodulation in Essential Tremor
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study is being done to test whether low-intensity focused ultrasound (LIFU) (low energy sound waves) cause temporary changes in brain activity and behavior when directed at particular parts of the brain. By targeting LIFU to the parts of the brain thought to be responsible for essential tremor (ET), and measuring any associated improvement in tremor, the investigators hope to show that LIFU can be a useful tool for studying the brain circuits responsible for tremor and other brain disorders.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with medically refractory tremor scheduled to undergo MR-guided high-intensity focused ultrasound (HIFU) thalamotomy to treat their tremor at UCSF.
Locations
United States
California
Pritzker Building, UCSF
RECRUITING
San Francisco
Contact Information
Primary
Leo P. Sugrue, MD, PhD
leo.sugrue@ucsf.edu
415-353-9056
Backup
Tommaso Di Ianni, PhD
tommaso.diianni@ucsf.edu
Time Frame
Start Date: 2024-10
Estimated Completion Date: 2027-03
Participants
Target number of participants: 60
Treatments
Experimental: To determine the most effective stimulation parameters for DRTT LIFU neuromodulation.
Investigators will record wrist accelerometer signals while participants maintain standardized postures that maximally elicit their tremor before, during, and after delivering LIFU stimulation.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Francisco
Collaborators: Focused Ultrasound Foundation