Novel DNA Adductomics Methodological Developments for Research in Colon Cancer
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls. In addition, surrogate samples such as white blood cells are investigated for the presense of adducts while blood plasma and urine are investigated for the presense of DNA-repair products.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Patients with either FAP, Lynch syndrome, other HNPCC, sporadic colorectal cancer, ulcerative colitis or other conditions who are scheduled for whole or partial resection of their colon
Locations
Other Locations
Denmark
Department of Nutrition, Exercise and Sports, University of Copenhagen
RECRUITING
Copenhagen
Contact Information
Primary
Lars Ove Drasted, professor
ldra@nexs.ku.dk
+4535332694
Backup
Giorgia La Barbera
glb@nexs.ku.dk
+4591838577
Time Frame
Start Date: 2021-02-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 60
Treatments
CRC
Patient affected by any sporadic colorectal cancer
FAP
Patients affected by familial adenomatous polyposis coli
HNPCC
Patient affected by hereditary non polyposis colorectal cancer
Lynch
patient affected by lynch syndrome
others
Patients affected by ulcerative colitis, chron disease, diverticulitis and other colon diseases, which represent the control
Related Therapeutic Areas
Sponsors
Collaborators: Hvidovre University Hospital
Leads: University of Copenhagen