Impact of Genetic Testing and Motivational Counseling on the Adherence to Healthy Lifestyle and Hypolipidemic Therapy and Efficiency of Cascade Screening in Patients With Familial Hypercholesterolemia (GENMOTIV-FH)
Status: Active_not_recruiting
Location: See location...
Intervention Type: Genetic, Diagnostic test, Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To date, there are highly effective lipid-lowering drugs, the combination of which makes it possible to achieve the target level of LDL-C in most patients with familial hypercholesterolemia (FH). However, the effectiveness of treatment of FH patients strongly depends on adherence to lipid-lowering therapy and to the healthy lifestyle, as well as the detection of the disease and the therapy prescription as early as possible, better in childhood. The aim of the study is to assess the impact of genetic testing and motivational counseling on the effectiveness of treatment and cascade screening in patients with FH.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Probable or definite diagnosis of FH according to the Dutch criteria (6 points or more);
• Signed informed consent;
Locations
Other Locations
Russian Federation
National Medical Research Centre for Therapy and Preventive Medicine of the Ministry of Health of Russia
Moscow
Time Frame
Start Date: 2020-06-15
Completion Date: 2025-03-30
Participants
Target number of participants: 180
Treatments
Active_comparator: Group 1 - without genetic testing; subgroup without motivational counseling
Group 1 - without genetic testing; subgroup without motivational counseling
Experimental: Group 1 - without genetic testing; subgroup with motivational counseling
Group 1 - without genetic testing; subgroup with motivational counseling
Experimental: Group 2 - with genetic testing; subgroup without motivational counseling
Group 2 - genetic testing has been performed; subgroup without motivational counseling.
Experimental: Group 2 - with genetic testing; subgroup with motivational counseling
Group 2 - genetic testing has been performed; subgroup with motivational counseling.
Authors
Related Therapeutic Areas
Sponsors
Collaborators: Moscow State University of Medicine and Dentistry
Leads: National Medical Research Center for Therapy and Preventive Medicine