Learn About Familial Hypertriglyceridemia

What is the definition of Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is a common disorder passed down through families. It causes a higher-than-normal level of triglycerides (a type of fat) in a person's blood.

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What are the alternative names for Familial Hypertriglyceridemia?

Type IV hyperlipoproteinemia

What are the causes of Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is mostly likely caused by genetic defects combined with environmental factors. As a result, the condition clusters in families. How severe the disorder is can vary based on sex, age, hormone use, and dietary factors.

People with this condition also have high levels of very low density lipoprotein (VLDL). LDL cholesterol and HDL cholesterol are often low.

In most cases, familial hypertriglyceridemia is not noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are often present as well. These factors may cause even higher triglyceride levels. Alcohol, a diet high in carbohydrates, and estrogen use can make the condition worse.

You are more likely to have this condition if you have a family history of hypertriglyceridemia or heart disease before age 50.

What are the symptoms of Familial Hypertriglyceridemia?

You may not notice any symptoms. Some people with the condition may have coronary artery disease at an early age.

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What are the current treatments for Familial Hypertriglyceridemia?

The goal of treatment is to control conditions that can raise triglyceride levels. These include obesity, hypothyroidism, and diabetes.

Your provider may tell you not to drink alcohol. Certain birth control pills can raise triglyceride levels. Talk to your provider about your risk when deciding whether to take these medicines.

Treatment also involves avoiding excess calories and foods high in saturated fats and carbohydrates.

Healthy diet

You may need to take medicine if your triglyceride levels stay high even after making diet changes. Nicotinic acid, gemfibrozil, and fenofibrate have been shown to lower triglyceride levels in people with this condition.

Who are the top Familial Hypertriglyceridemia Local Doctors?
Highly rated in

Houston Methodist

Psychiatry Clinic

6655 Travis St 
Houston, TX 

Christie Ballantyne is a Cardiologist in Houston, Texas. Ballantyne has been practicing medicine for over 40 years and is rated as an Elite expert by MediFind in the treatment of Familial Hypertriglyceridemia. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are Atherosclerosis, High Cholesterol, Familial Hypertriglyceridemia, and Coronary Heart Disease. He is licensed to treat patients in Texas. Ballantyne is currently accepting new patients.

Highly rated in
Internal Medicine

Penn Medicine

Perelman Center For Advanced Medicine

3400 Civic Center Blvd 
Philadelphia, PA 

Daniel Rader is an Internal Medicine expert in Philadelphia, Pennsylvania. Rader has been practicing medicine for over 38 years and is rated as an Elite expert by MediFind in the treatment of Familial Hypertriglyceridemia. He is also highly rated in 34 other conditions, according to our data. His top areas of expertise are High Cholesterol, Familial Hypercholesterolemia, Coronary Heart Disease, and Homozygous Familial Hypercholesterolemia HoFH. He is licensed to treat patients in Pennsylvania. Rader is currently accepting new patients.

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Highly rated in
Medical Genetics

14 Cherrywood Ct 
Cherry Hill, NJ 

Masako Ueda is an Endocrinologist and a Medical Genetics expert in Cherry Hill, New Jersey. Ueda is rated as an Elite expert by MediFind in the treatment of Familial Hypertriglyceridemia. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Familial Hypertriglyceridemia, Familial Lipoprotein Lipase Deficiency, Apolipoprotein C2 Deficiency, and Costello Syndrome. She is licensed to treat patients in New Jersey.

What is the outlook (prognosis) for Familial Hypertriglyceridemia?

Losing weight and keeping diabetes under control helps improve the outcome.

What are the possible complications of Familial Hypertriglyceridemia?

Complications may include:

  • Pancreatitis
  • Coronary artery disease
How do I prevent Familial Hypertriglyceridemia?

Screening family members for high triglycerides may detect the disease early.

What are the latest Familial Hypertriglyceridemia Clinical Trials?
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients With Severe Hypertriglyceridemia
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A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of MN-001 in Patients Diagnosed With Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia
What are the Latest Advances for Familial Hypertriglyceridemia?
Pandemics of the 21st Century: The Risk Factor for Obese People.
Vascular remodeling with violations of intracardiac hemodynamics in patients older age category, combined with the clinical-cluster, neurocognitive and biomarker heterogeneity in multifocal atherosclerosis.
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Misdiagnosis of Paget's Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report.
Who are the sources who wrote this article ?

Published Date: April 30, 2020
Published By: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 48.

Robinson JG. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 195.