Learn About Familial Hypertriglyceridemia

What is the definition of Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is a common disorder passed down through families. It causes a higher-than-normal level of triglycerides (a type of fat) in a person's blood.

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What are the alternative names for Familial Hypertriglyceridemia?

Type IV hyperlipoproteinemia

What are the causes of Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is mostly likely caused by genetic defects combined with environmental factors. As a result, the condition clusters in families. How severe the disorder is can vary based on sex, age, hormone use, and dietary factors.

People with this condition also have high levels of very low density lipoprotein (VLDL). LDL cholesterol and HDL cholesterol are often low.

In most cases, familial hypertriglyceridemia is not noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are often present as well. These factors may cause even higher triglyceride levels. Alcohol, a diet high in carbohydrates, and estrogen use can make the condition worse.

You are more likely to have this condition if you have a family history of hypertriglyceridemia or heart disease before age 50.

What are the symptoms of Familial Hypertriglyceridemia?

You may not notice any symptoms. Some people with the condition may have coronary artery disease at an early age.

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What are the current treatments for Familial Hypertriglyceridemia?

The goal of treatment is to control conditions that can raise triglyceride levels. These include obesity, hypothyroidism, and diabetes.

Your provider may tell you not to drink alcohol. Certain birth control pills can raise triglyceride levels. Talk to your provider about your risk when deciding whether to take these medicines.

Treatment also involves avoiding excess calories and foods high in saturated fats and carbohydrates.

Healthy diet

You may need to take medicine if your triglyceride levels stay high even after making diet changes. Nicotinic acid, gemfibrozil, and fenofibrate have been shown to lower triglyceride levels in people with this condition.

Who are the top Familial Hypertriglyceridemia Local Doctors?
Elite
Highly rated in
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Cardiology

Psychiatry Clinic

Houston, TX 

C Ballantyne is a Cardiologist in Houston, Texas. Dr. Ballantyne has been practicing medicine for over 40 years and is rated as an Elite doctor by MediFind in the treatment of Familial Hypertriglyceridemia. She is also highly rated in 26 other conditions, according to our data. Her top areas of expertise are Atherosclerosis, High Cholesterol, Familial Hypertriglyceridemia, and Coronary Heart Disease. She is board certified in Cardiovascular Disease (Cardiology) and Internal Medicine and licensed to treat patients in Texas. Dr. Ballantyne is currently accepting new patients.

Elite
Highly rated in
30
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Internal Medicine

Perelman Center For Advanced Medicine

Philadelphia, PA 

Daniel Rader is an Internal Medicine doctor in Philadelphia, Pennsylvania. Dr. Rader has been practicing medicine for over 38 years and is rated as an Elite doctor by MediFind in the treatment of Familial Hypertriglyceridemia. He is also highly rated in 30 other conditions, according to our data. His top areas of expertise are High Cholesterol, Familial Hypercholesterolemia, Coronary Heart Disease, and Atherosclerosis. He is board certified in Internal Medicine and licensed to treat patients in Pennsylvania. Dr. Rader is currently accepting new patients.

 
 
 
 
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Elite
Highly rated in
22
conditions
Gastroenterology

Cleveland Clinic Main Campus

Cleveland, OH 

Prabhleen Chahal is a Gastroenterologist in Cleveland, Ohio. Dr. Chahal has been practicing medicine for over 24 years and is rated as an Elite doctor by MediFind in the treatment of Familial Hypertriglyceridemia. She is also highly rated in 22 other conditions, according to our data. Her top areas of expertise are Acute Pancreatitis, Hereditary Pancreatitis, Familial Hypertriglyceridemia, and Cholecystitis. She is board certified in Gastroenterology and Internal Medicine and licensed to treat patients in Ohio. Dr. Chahal is currently accepting new patients.

What is the outlook (prognosis) for Familial Hypertriglyceridemia?

Losing weight and keeping diabetes under control helps improve the outcome.

What are the possible complications of Familial Hypertriglyceridemia?

Complications may include:

  • Pancreatitis
  • Coronary artery disease
How do I prevent Familial Hypertriglyceridemia?

Screening family members for high triglycerides may detect the disease early.

What are the latest Familial Hypertriglyceridemia Clinical Trials?
Phase III, Multicentre, Randomized, Double-blind, Placebo-controlled Trial Evaluating the Efficacy and Safety of SHR-1209 Monotherapy in Patients With Primary Hypercholesterolemia and Mixed Hyperlipemia
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Gut Microbiota Dependent and Independent Impacts of Dietary Pulses on Pre- and Postprandial Metabolism and Inflammation in Overweight/Obese Humans
What are the Latest Advances for Familial Hypertriglyceridemia?
Selective targeting of angiopoietin-like 3 (ANGPTL3) with vupanorsen for the treatment of patients with familial partial lipodystrophy (FPLD): results of a proof-of-concept study.
Analysis of the impact on the health care budget and consumers of the use of the preparation of omega-3 acid ethyl esters90 in the treatment of patients with atherogenic dyslipidemia.
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Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study.
What are our references for Familial Hypertriglyceridemia?

Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 48.

Robinson JG. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 195.