What is the definition of Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is a common disorder passed down through families. It causes a higher-than-normal level of triglycerides (a type of fat) in a person's blood.

What are the alternative names for Familial Hypertriglyceridemia?

Type IV hyperlipoproteinemia

What are the causes for Familial Hypertriglyceridemia?

Familial hypertriglyceridemia is mostly likely caused by genetic defects combined with environmental factors. As a result, the condition clusters in families. How severe the disorder is can vary based on sex, age, hormone use, and dietary factors.

People with this condition also have high levels of very low density lipoprotein (VLDL). LDL cholesterol and HDL cholesterol are often low.

In most cases, familial hypertriglyceridemia is not noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are often present as well. These factors may cause even higher triglyceride levels. Alcohol, a diet high in carbohydrates, and estrogen use can make the condition worse.

You are more likely to have this condition if you have a family history of hypertriglyceridemia or heart disease before age 50.

What are the symptoms for Familial Hypertriglyceridemia?

You may not notice any symptoms. Some people with the condition may have coronary artery disease at an early age.

What are the current treatments for Familial Hypertriglyceridemia?

The goal of treatment is to control conditions that can raise triglyceride levels. These include obesity, hypothyroidism, and diabetes.

Your provider may tell you not to drink alcohol. Certain birth control pills can raise triglyceride levels. Talk to your provider about your risk when deciding whether to take these medicines.

Treatment also involves avoiding excess calories and foods high in saturated fats and carbohydrates.


You may need to take medicine if your triglyceride levels stay high even after making diet changes. Nicotinic acid, gemfibrozil, and fenofibrate have been shown to lower triglyceride levels in people with this condition.

What is the outlook (prognosis) for Familial Hypertriglyceridemia?

Losing weight and keeping diabetes under control helps improve the outcome.

What are the possible complications for Familial Hypertriglyceridemia?

Complications may include:

  • Pancreatitis
  • Coronary artery disease

How do I prevent Familial Hypertriglyceridemia?

Screening family members for high triglycerides may detect the disease early.


Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 48.

Robinson JG. Disorders of lipid metabolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 195.

  • Condition: Patients with High Blood Lipids
  • Journal: Current atherosclerosis reports
  • Treatment Used: Lipid Lowering Drugs
  • Number of Patients: 0
  • Published —
This article discusses the treatment of patients with high blood lipids with lipid lowering drugs.
  • Condition: Severe Hypertriglyceridemia
  • Journal: Cardiovascular diabetology
  • Treatment Used: Pemafibrate
  • Number of Patients: 3
  • Published —
This study reported on patients with severe hypertriglyceridemia (high blood triglycerides) who were treated with pemafibrate.