Learn About Familial Hypofibrinogenemia

What is the definition of Familial Hypofibrinogenemia?
Familial hypofibrinogenemia is an inherited (genetic) disorder of blood clotting characterized by mild bleeding after trauma or surgery due to decreased blood plasma fibrinogen (clotting factor). Slightly more than 50% of individuals who inherit familial hypofibrinogenemia are the product of closely-related parents (consanguinity).
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What are the symptoms of Familial Hypofibrinogenemia?
Some individuals with familial hypofibrinogenemia do not experience any symptoms unless injured or after undergoing surgery. Symptoms of familial hypofibrinogenemia may include nosebleeds, gastrointestinal bleeding, bleeding of the gums, miscarriages in women, and, rarely, liver disease due to bleeding.
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What are the current treatments for Familial Hypofibrinogenemia?
Treatment for familial hypofibrinogenemia involves the use of fibrinogen replacement therapy.
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What are the latest Familial Hypofibrinogenemia Clinical Trials?
Obstetric Outcomes of Women Suffering From Hereditary Fibrinogen Disorders

Summary: The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as to describe pregnancies outcomes in such diseases.

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What are the Latest Advances for Familial Hypofibrinogenemia?
Congenital Fibrinogen Deficiency Caused by Novel FGG Gene Mutation.
Rare severe hypofibrinogenemia induced by tissue plasminogen activator in stroke patients: Case report.
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Paradoxical pulmonary hemorrhage associated with hemocoagulase batroxobin in a patient with hemoptysis: A CARE-compliant case report.