A Study of Efbemalenograstim Alfa Injection for Ovarian or Cervical Cancer Receiving Chemotherapy Regimen With Risk Factors:A Single-Arm, Multicenter Clinical Trial

Status: Recruiting
Location: See all (6) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The aim of this study was to observe the efficacy and safety of Efbemalenograstim Alfa in the prevention of absolute neutrophil count (ANC) reduction after chemotherapy in Ovarian and Cervical cancer patients at risk of platinum-containing chemotherapy with risk factors in febrile neutropenia (FN).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• ≥ 18 years old and ≤ 70 years old.

• First-line epithelial ovarian cancer (including fallopian tube cancer and primary peritoneal cancer) and first-line treatment or recurrent/metastatic cervical cancer.

• Planned to receive 3-6 cycles of paclitaxel + carboplatin/cisplatin ± bevacizumab therapy.

• Eastern Cooperative Oncology Group (ECOG) score \< 2.

• Expected survival time \> 3 months.

• Before enrollment, neutrophil count (ANC) ≥ 2.0 × 10\^9/L, hemoglobin (Hb) ≥ 90.0 g/L, and platelet (PLT) ≥ 80 × 10\^9/L.

• Associated with ≥ 1 self-factors increasing the risk of febrile neutropenia (FN): ① age \> 65 years, receiving full-dose intensity chemotherapy; ② history of previous chemotherapy or radiotherapy; ③ persistent neutropenia; ④ tumor involvement of the bone marrow; ⑤ recent surgery and/or open wounds; ⑥ hepatic dysfunction (bilirubin \> 2.0 mg•dL-1); ⑦ renal dysfunction (creatinine clearance rate \< 50 mL•min-1); ⑧ history of previous FN occurrence; ⑨ concomitant malignant hematological or lymphatic system diseases; ⑩ chronic immunosuppression; ⑪ poor nutritional/physical status. Individualized judgment and decision-making based on the patient's specific condition are required in clinical practice.

• Left ventricular ejection fraction (LVEF) \> 50%.

• Women who are not capable of reproduction, i.e., postmenopausal for at least 1 year or have undergone sterilization procedures (bilateral tubal ligation, bilateral oophorectomy, or hysterectomy). Fertile patients agree to use appropriate contraceptive measures within 1 month before the start of the trial and up to 30 days after the end of the study, such as condoms, spermicidal condoms, foam, gel, diaphragm, intrauterine device (IUD), contraceptive pills (oral or injectable), etc.

⁃ Willing to provide written informed consent and to compliant study procedure.

⁃ The investigator determines that the patient can tolerate treatment with Efgbemalenograstim alfa.

Locations
Other Locations
China
Xiangya Hospital, Central South University,
NOT_YET_RECRUITING
Changsha
Zhejiang Cancer Hospital
NOT_YET_RECRUITING
Hangzhou
Qilu Hospital of Shandong University
RECRUITING
Jinan
Zhongda Hospital, School of Medicine, Southeast University
NOT_YET_RECRUITING
Nanjing
Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University,
NOT_YET_RECRUITING
Qingdao
Shanxi Provincial Cancer Hospital
NOT_YET_RECRUITING
Taiyuan
Contact Information
Primary
Limei Wang
18560081708@163.com
18560081708
Time Frame
Start Date: 2024-04-15
Estimated Completion Date: 2026-12
Participants
Target number of participants: 83
Treatments
Experimental: experimental group
Efbemalenograstim Alfa should be administered subcutaneously, 20mg per injection, within 24-48 hours after the completion of each chemotherapy cycle.
Sponsors
Collaborators: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Leads: Shandong University

This content was sourced from clinicaltrials.gov