Learn About Fibrous Dysplasia
Fibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected.
Inflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia; McCune-Albright syndrome
Fibrous dysplasia usually occurs in childhood. Most people have symptoms by the time they are 30 years old. The disease occurs more often in females.
Fibrous dysplasia is linked to a problem with genes (gene mutation) that control bone-producing cells. The mutation occurs when a baby is developing in the womb. The condition is not passed from parent to child.
Symptoms may include any of the following:
- Bone pain
- Bone sores (lesions)
- Hormone (endocrine gland) problems
- Fractures or bone deformities
- Unusual skin color (pigmentation), which occurs with McCune-Albright syndrome
The bone lesions may stop when the child reaches puberty.
There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as needed. Hormone problems will need to be treated.
CHU Edouard Herriot
Roland Chapurlat practices in Lyon, France. Mr. Chapurlat is rated as an Elite expert by MediFind in the treatment of Fibrous Dysplasia. His top areas of expertise are Postmenopausal Osteoporosis, Osteoporosis, Fibrous Dysplasia, Osteitis Fibrosa, and Hip Replacement.
Natasha Dijkstra-Appelman practices in Leiden, Netherlands. Ms. Dijkstra-Appelman is rated as an Elite expert by MediFind in the treatment of Fibrous Dysplasia. Her top areas of expertise are Fibrous Dysplasia, Mccune-Albright Syndrome, Osteitis Fibrosa, Parathyroidectomy, and Hormone Replacement Therapy (HRT).
Bas Majoor practices in Leiden, Netherlands. Majoor is rated as an Elite expert by MediFind in the treatment of Fibrous Dysplasia. Their top areas of expertise are Fibrous Dysplasia, Osteitis Fibrosa, Mccune-Albright Syndrome, Precocious Puberty, and Bone Graft.
The outlook depends on the severity of the condition and the symptoms that occur.
Depending on the bones that are affected, health problems that may result include:
- If skull bone is affected, there can be vision or hearing loss
- If a leg bone is affected, there can be difficulty walking and joint problems such as arthritis
Contact your provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.
Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care.
There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.
Summary: Polyostotic fibrous dysplasia (PFD) is a sporadic disorder which affects multiple sites in the skeleton. The bone at these sites is rapidly resorbed and replaced by abnormal fibrous tissue or mechanically abnormal bone. PFD may occur alone or as part of the McCune-Albright Syndrome (MAS), a syndrome originally defined by the triad of PFD, cafe-au-lait pigmentation of the skin, and precocious puber...
Summary: The FD/MAS Patient Registry is an IRB-approved research study that that invites the patients and families to help answer some of the biggest questions about FD/MAS by completing questionnaires about their lives with FD or MAS. Have you enrolled in the FD/MAS Patient Registry yet? Are you up-to-date on your surveys? Take a trip to www.fdmasregistry.org today to learn more about the project, enroll,...
Published Date: November 06, 2023
Published By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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