Progressive Resistance Exercise and Dystonia Pathophysiology.
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 85
Healthy Volunteers: f
View:
• Patients have predominantly focal cervical dystonia and whose diagnosis will be confirmed by a movement disorders specialist following criteria recommended by Movement Disorders Society.
• Moderate disease severity.
• Are 30 to 85 years old
• Are able to tolerate exercise sessions.
• Reporting suboptimal clinical benefits despite receiving maximally tolerated doses of BoNT injections for the neck muscles and/or oral pharmacological therapy.
Locations
United States
Florida
University of Florida
RECRUITING
Gainesville
Time Frame
Start Date: 2022-10-13
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 56
Treatments
Experimental: Progressive resistance exercise (exercise group)
Subjects will receive physical therapy that will predominantly include progressive resistance exercise training program along with continuation of standard of care (exercise group)
Active_comparator: Standard of care (non-exercise group).
Subjects will receive continuation of standard of care (non-exercise group).
Related Therapeutic Areas
Sponsors
Leads: University of Florida
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)