Learn About Follicular Thyroid Cancer

View Main Condition: Thyroid Cancer

What is the definition of Follicular Thyroid Cancer?
Follicular thyroid cancer is a cancer that forms from the follicular cells of the thyroid and is the second most common type of thyroid cancer. It is more common in females. It usually affects people between the ages of 40 and 60 and can be an aggressive disease, as it characteristically invades blood vessels and spreads (metastasizes) to other parts of the body. A sub-type, Hurthle cell cancer, is a rare, more aggressive type of follicular thyroid cancer. While the exact cause is unclear, thyroid cancer develops when genetic mutations occur in thyroid cells that then reproduce rapidly, form a tumor, and spread to other areas, such as lung, bone, brain, liver, bladder, and skin.
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What are the symptoms of Follicular Thyroid Cancer?
Since individuals with follicular thyroid cancer can have no symptoms, the cancer is usually found during routine examination with the discovery of a neck mass or nodule, or after having an X-ray of the neck for another reason, or during other medical and/or diagnostic treatments. However, for individuals who do experience symptoms of follicular thyroid cancer, these symptoms can include a large, malignant neck mass more than 4 cm, a fixed mass, soft tissue invasion, vocal cord paralysis, and difficulty swallowing.
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What are the current treatments for Follicular Thyroid Cancer?
Treatments for follicular thyroid cancer depend on the mass and include hemi-thyroidectomy (partial removal of thyroid) and removal of the thyroid isthmus, or total thyroidectomy and the removal of neck lymph nodes. After surgery, patients may be placed on thyroid hormone replacement and should have the usual cancer care follow-up. The overall cure rate for follicular thyroid cancer is nearly 95% for small tumors in young patients; however, this rate decreases with age. If follicular thyroid cancer is treated early, it has a good prognosis.
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What are the latest Follicular Thyroid Cancer Clinical Trials?
A Phase 1, Open-label, Dose-escalation Study of SEA-CD40 in Adult Patients With Advanced Malignancies

Summary: This study is being done to find out if SEA-CD40 is safe and effective when given alone, in combination with pembrolizumab, and in combination with pembrolizumab, gemcitabine, and nab-paclitaxel. The study will test increasing doses of SEA-CD40 given at least every 3 weeks to small groups of patients. The goal is to find the highest dose of SEA-CD40 that can be given to patients that does not caus...

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Renal Tumors Classification, Biology, and Banking Study

Summary: This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.

What are the Latest Advances for Follicular Thyroid Cancer?
Successful treatment of a case with synchronous follicular lymphoma and gastric adenocarcinoma with CD19 CAR T cells and literature review.
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.
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Peptide receptor radionuclide therapy (PRRT) in radioiodine-refractory thyroid cancer: A case report of significant response to lu177 DOTA-TATE treatment.