Fungal ArthritisSymptoms, Doctors, Treatments, Advances & More
Learn About Fungal Arthritis
View Main Condition: Arthritis
Fungal arthritis is swelling and irritation (inflammation) of a joint by a fungal infection. It is also called mycotic arthritis.
Mycotic arthritis; Infectious arthritis - fungal
Fungal arthritis is a rare condition. It can be caused by any of the invasive types of fungi. The infection can result from an infection in another organ, such as the lungs which travels to a joint through the bloodstream. A joint can also become infected during a surgery or injury. People with weakened immune systems who travel or live in areas where specific fungi are common, are more susceptible to most causes of fungal arthritis.
Conditions that can cause fungal arthritis include:
- Blastomycosis
- Candidiasis
- Coccidioidomycosis
- Cryptococcosis
- Histoplasmosis
- Sporotrichosis
The fungus can affect bone or joint tissue. One or more joints can be affected, most often the large, weight-bearing joints, such as the knees.
Symptoms may include any of the following:
- Fever
- Joint pain
- Joint stiffness
- Joint swelling
- Swelling of the ankles, feet, and legs
The goal of treatment is to cure the infection using antifungal medicines. Commonly used antifungal medicines are amphotericin B or medicines in the azole family (fluconazole, ketoconazole, or itraconazole).
Chronic or advanced bone or joint infection may require surgery (debridement) to remove the infected tissue.
Preferred Internal Medicine
Candi Overholt is a primary care provider, practicing in Internal Medicine in Newport, Tennessee. Dr. Overholt is rated as an Experienced provider by MediFind in the treatment of Fungal Arthritis. She is also highly rated in 51 other conditions, according to our data. Her clinical expertise encompasses Type 2 Diabetes (T2D), Schnitzler Syndrome, Monoclonal Gammopathy of Undetermined Significance (MGUS), and Familial Hypertension. Dr. Overholt is board certified in American Board Of Internal Medicine.
Texas Health Family Care
Scott Simms is a primary care provider, practicing in Family Medicine in Denton, Texas. Dr. Simms is rated as an Advanced provider by MediFind in the treatment of Fungal Arthritis. He is also highly rated in 17 other conditions, according to our data. His clinical expertise encompasses High Cholesterol, Sciatica, Sitosterolemia, and Glucocorticoid-Remediable Aldosteronism.
Suburban Geriatrics Inc
Robert Pearlstein is a primary care provider, practicing in Geriatrics and Internal Medicine in Plymouth Meeting, Pennsylvania. Dr. Pearlstein is rated as an Experienced provider by MediFind in the treatment of Fungal Arthritis. He is also highly rated in 180 other conditions, according to our data. His clinical expertise encompasses Dementia, Alzheimer's Disease, Painful Swallowing, Gastrostomy, and Endoscopy. Dr. Pearlstein is board certified in .
How well you do depends on the underlying cause of the infection and your overall health. A weakened immune system, cancer, and certain medicines can affect the outcome.
Joint damage may occur and the risk of damage is higher if the infection is not treated right away.
Contact your provider if you have any symptoms of fungal arthritis.
Thorough treatment of fungal infections elsewhere in the body may help prevent fungal arthritis.
Published Date: December 13, 2025
Published By: Jatin M. Vyas, MD, PhD, Roy and Diana Vagelos Professor in Medicine, Columbia University Vagelos College of Physicians and Surgeons, Division of Infectious Diseases, Department of Medicine, New York, NY. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Denmeade TA, Ohl CA. Infectious arthritis of native joints. In: Blaser MJ, Cohen JI, Holland SM, et al, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 10th ed. Philadelphia, PA: Elsevier; 2026:chap 105.
Ruderman EM, Flaherty JP. Fungal infections of bones and joints. In: Firestein GS, McInnes IB, Koretzky GA, Mikuls TR, Neogi T, O'Dell JR, eds. Firestein and Kelley's Textbook of Rheumatology. 12th ed. Philadelphia, PA: Elsevier; 2025:chap 115.