Learn About Ganglioneuroblastoma

View Main Condition: Neuroblastoma

What is the definition of Ganglioneuroblastoma?

Ganglioneuroblastoma is an intermediate tumor that arises from nerve tissues. An intermediate tumor is one that is between benign (slow-growing and unlikely to spread) and malignant (fast-growing, aggressive, and likely to spread).

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What are the causes of Ganglioneuroblastoma?

Ganglioneuroblastoma mostly occurs in children ages 2 to 4 years. The tumor affects boys and girls equally. It occurs rarely in adults. Tumors of the nervous system have different degrees of differentiation. This is based on how the tumor cells look under the microscope. It can predict whether or not they are likely to spread.

Benign tumors are less likely to spread. Malignant tumors are aggressive, grow quickly, and often spread. A ganglioneuroma is less malignant in nature. A neuroblastoma (occurring in children over 1 year old) is usually malignant.

A ganglioneuroblastoma may be only in one area or it may be widespread, but it is usually less aggressive than a neuroblastoma. The cause is unknown.

What are the symptoms of Ganglioneuroblastoma?

Most commonly, a lump can be felt in the abdomen with tenderness.

This tumor may also occur at other sites, including:

  • Chest cavity
  • Neck
  • Legs
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What are the current treatments for Ganglioneuroblastoma?

Depending on the type of tumor, treatment can involve surgery, and possibly chemotherapy and radiation therapy.

Because these tumors are rare, they should be treated in a specialized center by experts who have experience with them.

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What are the support groups for Ganglioneuroblastoma?

More information and support for children with ganglioneuroblastoma and their families can be found at:

  • Children's Oncology Group -- www.childrensoncologygroup.org
  • The Neuroblastoma Children's Cancer Society -- neuroblastomachildrenscancersociety.org/
What is the outlook (prognosis) for Ganglioneuroblastoma?

The outlook depends on how far the tumor has spread, and whether some areas of the tumor contain more aggressive cancer cells.

What are the possible complications of Ganglioneuroblastoma?

Complications that may result include:

  • Complications of surgery, radiation, or chemotherapy
  • Spread of the tumor into surrounding areas
When should I contact a medical professional for Ganglioneuroblastoma?

Contact your provider if you feel a lump or growth on your child's body. Make sure children receive routine examinations as part of their well-child care.

What are the latest Ganglioneuroblastoma Clinical Trials?
Molecularly-Driven Doublet Therapy for All Children With Refractory or Recurrent CNS Malignant Neoplasms and Young Adults With Refractory or Recurrent SHH Medulloblastoma

Summary: Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy fails and how cancers continue to re...

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Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma

Summary: This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and...

What are the Latest Advances for Ganglioneuroblastoma?
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Robotic adrenalectomy in the pediatric population: initial experience case series from a tertiary center.
Who are the sources who wrote this article ?

Published Date: October 28, 2021
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Harrison DJ, Ater JL. Neuroblastoma. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 525.

Myers JL. Mediastinum. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. Rosai and Ackerman's Surgical Pathology. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 12.