The 20 Best Gangliosidosis Doctors Near Me in Dallas, TX

Recent advances have made the discovery of genetic susceptibility loci for complex human phenotypes a reality, including nervous system disorders. The critical next step will be to definitively identify the responsible genes and understand their functions in both health and disease. Our research integrates genetic investigation in human subjects and model organisms, with the goal of understanding brain function and aging, and improving the treatment of neurologic disease. We focus on Alzheimer's disease and Parkinson's disease, two incurable neurodegenerative disorders and experimental paradigms for the age-dependent failure of brain cognitive and motor control in humans. Human Genetics: The clinical manifestation of neurodegenerative disease is the culmination of a multi-tiered pathogenic cascade that evolves over decades; understanding how genetic variants impact this causal chain is essential. Although 2 percent of the population over age 65 are clinically diagnosed with Parkinson's disease, the defining pathology of disease (alpha-synuclein Lewy bodies) is discovered in 20 percent of brains from population-based autopsy studies. We are, therefore, investigating the impact of genomic variation on directly measured Lewy pathology, neuronal loss in the midbrain substantia nigra, and progressive motor impairment, leveraging human subject cohorts with detailed clinical and pathological data. In complementary investigations, we are deploying biosensor devices to improve detection of Parkinson's-related motor impairment, including the development of quantitative biometric phenotypes for genetic analyses of disease subtypes. We are also performing whole exome sequencing of individuals with familial Parkinson's disease and related disorders, and exploring potential links between inherited pediatric lysosomal and late-onset, adult neurodegenerative diseases. Drosophila Genetics: Despite the promise of current human genetic methods, such as genome-wide association studies and next generation sequencing, they often fail to definitively identify disease susceptibility genes and variants. We are, therefore, taking advantage of the rapid and powerful genetics available in the fruit fly Drosophila melanogaster in order to accelerate the validation of responsible genes and an understanding of their functions in the nervous system, including for disease pathogenesis. Expression of human amyloid-beta, Tau, or alpha-synuclein proteins in the fly nervous system recapitulates many core features of Alzheimer's disease and Parkinson's disease pathogenesis. We are testing candidate human susceptibility genes for functional genetic interactions in these fly models of neurodegeneration. Implicated molecular pathways are probed in greater depth, using both Drosophila and human genetic approaches. Current areas of interest include endolysosomal sorting, RNA metabolism/splicing, neuronal cell adhesion, and synaptic mechanisms of neurodegeneration. Dr. Shulman is rated as an Experienced provider by MediFind in the treatment of Gangliosidosis. He is also highly rated in 6 other conditions, according to our data. His clinical expertise encompasses Parkinson's Disease, Movement Disorders, Alzheimer's Disease, and Dementia. Dr. Shulman is currently accepting new patients.

Aziz Shaibani, MD, is dedicated to delivering high-quality, compassionate care to Houston and nearby communities. Aziz Shaibani specializes in Neurology (Brain and Spine) and works at Houston Neurocare P. A.. To make an appointment, please call (713) 795-0033. To review all accepted insurance carriers, please visit: https://www.stlukeshealth.org/patients-visitors/patients/billing-insurance/insurances-accepted. Dr. Shaibani is rated as an Experienced provider by MediFind in the treatment of Gangliosidosis. He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Inclusion Body Myositis, Myasthenia Gravis, Myositis, Chronic Inflammatory Demyelinating Polyneuropathy, and Thymectomy. Dr. Shaibani is currently accepting new patients.

Steven Gerhardt is a Neurologist practicing medicine in Dallas, Texas. Dr. Gerhardt is rated as an Experienced provider by MediFind in the treatment of Gangliosidosis. He is also highly rated in 31 other conditions, according to our data. His clinical expertise encompasses Stroke, Distal Median Nerve Dysfunction, Foot Drop, and Common Peroneal Nerve Dysfunction.

Dr. Macmurdo specializes in clinical genetics for children and adults at Baylor Scott & White McLane Children's Medical Center and Baylor Scott & White Medical Center in Temple, TX. A native of Chattanooga, Tennessee, she attended Rhodes College, earning a B.S. in chemistry with a concentration in biochemistry. She then attended medical school at the Edward Via College of Osteopathic Medicine at Virginia Tech in Blacksburg, VA. Dr. Macmurdo trained in pediatrics at UT COM Chattanooga and continued in fellowship in medical genetics at Stanford Hospital and clinics in California. Dr. Macmurdo joined the Baylor Scott and White team in 2015. For her clinical practice, she sees patients with suspected genetic disorders including the multidisciplinary clinics for Down syndrome and pediatric oncology. Dr. Macmurdo's areas of expertise include rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, ankylosing spondylitis, inflammatory myositis, and vasculitis. Connect with Dr. Macmurdo: Colleen Forsyth Macmurdo, DO, FACMG | LinkedIn Dr. Macmurdo on Doximity. Dr. Macmurdo is rated as an Experienced provider by MediFind in the treatment of Gangliosidosis. Her clinical expertise encompasses Microcephaly, Increased Head Circumference, Neurofibromatosis Type 1 (NF1), and Neurofibromatosis. Dr. Macmurdo is board certified in Clinical Genetics And Genomics (MD)- American Board Of Medical Genetics And Genomics.

Lindsay Elton is a Pediatric Neurologist practicing medicine in Austin, Texas. Dr. Elton is rated as an Experienced provider by MediFind in the treatment of Gangliosidosis. She is also highly rated in 13 other conditions, according to our data. Her clinical expertise encompasses Migraine, Migraine with Brainstem Aura, Benign Rolandic Epilepsy, and Apraxia. Dr. Elton is currently accepting new patients.