Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks' postmenstrual age), the most severe disease form. This study aims to (1) generate the first empirically defined phenotype classification system for grade 3 BPD developed using a rich array of objective and quantitative cardiopulmonary diagnostic, clinical, and biological data; and (2) define the association between phenotype subgroups and neurodevelopmental and respiratory outcomes through 2 years' corrected age.
• Male or female infant born with gestational age \<32 weeks
• Postmenstrual age between 36-65 weeks at enrollment
• Receiving invasive ventilation at enrollment
• Grade 3 BPD or grade 2 BPD with need for chronic invasive ventilation at enrollment
• Parental informed consent (provides the consent to participate)
• Parent or legal guardian of an enrolled infant subject
• Informed consent