Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
• Singleton, full term pregnancy within the past 5 years
• Hemoglobin HbA1c ≤5.6% and fasting blood glucose \<100 mg/dl
• Body mass index ≥30.0 kg/m2 and \<45.0 kg/m2, because the majority of women with GDM have overweight/obesity
⁃ Group specific inclusion criteria:
• Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
• Control Group: no history of gestational diabetes