Comprehensive Assessment of Tumor Stiffness and Adhesion in Glioma Using Magnetic Resonance Elastography: A Prospective Study
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffness and adhesion with molecular and genetic characteristics of gliomas. Additionally, the predictive value of MRE in terms of pathological staging and prognosis will be determined. This research may pave the way for improved clinical decision-making, personalized treatment approaches, and more accurate clinical trials for glioma patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
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• All patients undergoing glioma resection surgery are eligible for inclusion in the study cohort.
Locations
Other Locations
China
Shengjing Hospital
RECRUITING
Shenyang
Contact Information
Primary
Yu Shi, MD
18940259980@163.com
+86 189 4025 9980
Backup
Wen Cheng, MD
cmu071207@163.com
+86 150 4023 5535
Time Frame
Start Date: 2017-07-01
Estimated Completion Date: 2027-07-01
Participants
Target number of participants: 100
Treatments
Experimental: Diagnostic (MRE, tumor grade, tumor stiffness and adhesion)
Patients undergo a preoperative routine MRI scan and MRE the day before their scheduled surgery to assess tumor stiffness and adhesion. Additionally, molecular pathological analysis will be performed to identify genetic alterations in gliomas. During surgery, the tumor stiffness and adhesion will be assessed and recorded by the surgeon according to established evaluation criteria.~It is important to note that the surgeon does not have prior knowledge of the tumor's specific stiffness before the surgery. This information is typically obtained through intraoperative assessment and observation.
Related Therapeutic Areas
Sponsors
Leads: Shengjing Hospital