Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA, Tako-Tsubo, SCAD, Myocarditis and NSTEMI in the Acute Phase and Post Convalescence

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR. The present study aims to: * assess the microvascular function with a novel quantitative 3D myocardial perfusion imaging approach in the acute phase and post-convalescence * refine the role and diagnostic potential of advanced quantitative CMR imaging * assess the potential prognostic significance of microvascular dysfunction and epicardial adipose tissue on cardiovascular outcomes Participants will undergo advanced CMR imaging in the acute setting (within 10 days after event) and post convalescence (after 3 months).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• acute presentation with signs/symptoms of acute coronary syndrome or myocarditis

• elevated cardiac biomarkers

• no signficant coronary artery disease on coronary angiogram or coronary CT

Locations
Other Locations
Switzerland
University Hospital Zurich
RECRUITING
Zurich
Contact Information
Primary
Robert Manka, Prof., MD
robert.manka@usz.ch
+41442551251
Backup
Verena C Wilzeck, MD
verena.wilzeck@usz.ch
Time Frame
Start Date: 2023-06-15
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 75
Treatments
Experimental: MINOCA
Patients with myocardial infarction with non-obstructive coronary artery disease (MINOCA) prospectively investigated with advanced CMR
Experimental: Myocarditis
Patients with suspected myocarditis prospectively investigated with advanced CMR
Experimental: Takotsubo cardiomyopathy
Patients with suspected Takotsubo cardiomyopathy prospectively investigated with advanced CMR
Experimental: Spontaneous coronary artery dissection (SCAD)
Patients with suspected/diagnosed spontaneous coronary artery dissection prospectively investigated with advanced CMR
Active_comparator: NSTEMI
Patients with confirmed non-ST elevation myocardial infarction on coronary angiography prospectively investigated with advanced CMR
Sponsors
Collaborators: ETH Zurich
Leads: University of Zurich

This content was sourced from clinicaltrials.gov