Association of Heterogeneous Circulating Biomarkers and Anamnestic Factors of Pregnancy Adverse Course and Outcomes With the Prognosis of Heart Failure With Preserved Ejection Fraction

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The primary purpose of this study is to evaluate possible association of some heterogeneous circulating biomarkers and anamnestic factors of pregnancy adverse course and outcomes with the prognosis of heart failure with preserved ejection fraction. The study population includes women aged 60-74 years with history of pregnancy with duration at least 20 weeks and diagnosed heart failure with preserved ejection fraction based on algorithm HFA-PEFF. The following pregnancy complications are assessed on the initial visit: gestational hypertension, preeclampsia, gestation diabetes mellitus and recently introduced as cardiovascular disease risk factors preterm delivery, stillbirth, miscarriage. This information is collected through a questionnaire which additionally includes questions about menopause and the circumstances of its onset. The data about comorbidities, results of laboratory and instrumental tests is collected from medical records. After the interview short physical examination is performed to measure anthropometric data and objective signs of congestion. In addition, medical Research Council Scale survey is conducted to assess the subjective severity of shortness of breath and a six-minute walking test to objectively evaluate the heart failure functional class. After inclusion in the study blood sampling is performed to measure the concentration of a number of biomarkers which are recognized as prognostically significant in context of heart failure: high-sensitivity troponin I, soluble suppression of tumorigenicity 2 protein, heat shock protein 27, cystatin C. As part of the study echocardiography is also performed with evaluation of left ventricular global longitudinal strain and left atrial strain to assess systolic and diastolic myocardium function. 12 months after the initial visit, participants are contacted by telephone. The data about newly diagnosed chronic non-communicable diseases, emergency hospitalization for any cause and major adverse cardiovascular events is collected. If there is no response from the research participant, the cause, including possible hospitalization or death, is determined by telephone contact with the participant's trusted person.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 60
Maximum Age: 74
Healthy Volunteers: f
View:

• Women aged 60-74 years

• Heart failure with preserved ejection fraction (diagnosed by using HFA-PEFF algorithm)

• History of pregnancy with duration at least 20 weeks

• Willing and legally able to sign informed consent

Locations
Other Locations
Russian Federation
Federal State Budgetary Institution National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthсare of the Russian Federation
RECRUITING
Moscow
Contact Information
Primary
Vasilisa Kosulina, MD
vasilisa.kosulina@mail.ru
+7-996-981-40-27
Backup
Olga Dzhioeva, MD, PhD
odzhioeva@gnicpm.ru
+7-916-614-18-21
Time Frame
Start Date: 2024-11-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 100
Treatments
Patients with anamnestic factors of pregnancy adverse course and outcomes
Patients without anamnestic factors of pregnancy adverse course and outcomes
Sponsors
Leads: National Medical Research Center for Therapy and Preventive Medicine

This content was sourced from clinicaltrials.gov