Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Maximum Age: 90
Healthy Volunteers: t
View:
• signs and symptoms of heart failure
• an ejection fraction \> 0.50;
• objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
• healthy volunteers
Locations
United States
Texas
UT Southwestern Medical Center
RECRUITING
Dallas
Contact Information
Primary
Raksa B Moran, RN
raksamoran@texashealth.org
214-345-6574
Backup
Jessica N Alcala, RN
jessicaalcala@texashealth.org
214-345-6574
Time Frame
Start Date: 2023-07-01
Estimated Completion Date: 2029-06-30
Participants
Target number of participants: 78
Treatments
Experimental: HeO2 gas mixture, then Room air gas mixture
Participant will be randomized to each intervention on separate days (Study visit 3 and 4) in this cross-over trial. Participants that receive HeO2 first will then receive the room air gas mixture. At least 24 hours will separate each visit.
Experimental: Room air gas mixture, then HeO2 gas mixture
Participant will be randomized to each intervention on separate days (Study visit 3 and 4) in this cross-over trial. Participants that receive Room air first will then receive the HeO2 mixture. At least 24 hours will separate each visit.
Related Therapeutic Areas
Sponsors
Leads: University of Texas Southwestern Medical Center