The Effects of Obesity and Weight Loss in Heart Failure: Imaging the Obesity Paradox Using Magnetic Resonance Imaging and Spectroscopy - Heart Failure With Preserved Ejection Fraction Substudy

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study looks at the effects of weight loss in people who have heart failure with preserved ejection fraction (HFpEF) and are overweight or obese. The main questions it aims to answer are whether weight loss in this group of people improves: 1. The heart's shape, how well it pumps blood and how well it uses fuels 2. The person's quality of life and how much they can exercise Participants will attend 2 study visits, separated by 3-6 months. The intervention period takes place in between the 2 study visits. Each study visit will involve measurements including: * Symptom and quality of life questionnaires * Body measurements such as height and weight * Blood tests * Ultrasound scans of the heart (echocardiogram) * Magnetic Resonance Imaging (MRI) scans of the heart * Exercise components during the scans * 6 minute walk test Participants are randomly allocated (in other words, by lottery) to either 'diet' or 'control' groups. The control group will continue standard care. The diet group will be enrolled in a weight loss program supervised by the study team. Participants in the diet group will replace their usual meals with meal replacement products specifically designed to deliver a low calorie diet for weight loss. The products will consist of formula soups, shakes and porridges. This diet would last 8 weeks, followed by a guided period of food reintroduction and maintenance.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Heart failure with preserved ejection fraction (HFpEF)

• Left ventricular ejection fraction (LVEF) =/\> 50%

• Body Mass Index (BMI) approximately =/\> 27.5 kg/m\^2

Locations
Other Locations
United Kingdom
Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital
RECRUITING
Oxford
Contact Information
Primary
Jiliu Pan, BMBCh
jiliu.pan@cardiov.ox.ac.uk
+44(0)1865234591
Backup
Jenny Rayner, DPhil
jenny.rayner@cardiov.ox.ac.uk
+44(0)1865221172
Time Frame
Start Date: 2023-01-20
Estimated Completion Date: 2026-12
Participants
Target number of participants: 120
Treatments
Experimental: Diet
Diet intervention (in addition to standard clinical care)
No_intervention: Control
Standard clinical care only
Sponsors
Leads: University of Oxford
Collaborators: British Heart Foundation

This content was sourced from clinicaltrials.gov