The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
• Adults 18-75 years old
• Normal kidney function
• No heart failure
• BMI 25-30kg/m2
• Adults 18-75 years old
• eGFR \>= 60 mL/min/1.73m2
• BMI \> 35 kg/m2
• Adults 18-75 years old
• eGFR \>= 60 mL/min/1.73m2
• BMI \> 35 kg/m2
• Diagnosis of HFpEF (chart diagnosis, LVEF \> 55% on echo, H2FPEF score 6-9 or HFA-PEFF score 5 or 6