IMPact of Donor Heart Function on Recipient Outcomes - a prospectiVE Study to Increase the Utilization of Donor HEARTs

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Severe heart failure is a diagnosis with a very poor prognosis. Heart transplantation is the best treatment for terminal heart failure but this type of treatment is limited by the number of available organs. About 20-25% of possible donor hearts are not considered for transplantation because they have some form of functional impairment. The functional impairment affecting organ donors is, however, usually reversible. A number of retrospective studies show that cardiac function recovers and recipients of hearts with dysfunction do not have worse outcomes compared to recipients of hearts with perfect cardiac function. However, there are no prospective studies on whether the functional impairment of the donor heart is of significance for the recipient. With a systematic and simple investigation of the heart, it should be possible to identify the hearts that are safe to transplant. This will thus increase the number of available donors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient who has been accepted for heart transplantation at the participating transplantation center

‣ The research subject has given written consent to participate in the study

⁃ Aged 18 years or older

Locations
Other Locations
Sweden
Sahlgrenska University Hostpial
RECRUITING
Gothenburg
Contact Information
Primary
Jonatan Oras, MD, PhD
jonatan.oras@vgregion.se
+46736370350
Time Frame
Start Date: 2022-04-05
Estimated Completion Date: 2027-04-01
Participants
Target number of participants: 500
Treatments
recipients of hearts with impaired function
Patient who has been accepted for heart transplantation at the participating transplantation center and who will receive heart with impaired function
recipients of hearts with normal function
Patient who has been accepted for heart transplantation at the participating transplantation center and who will receive heart with normal function
Sponsors
Leads: Vastra Gotaland Region

This content was sourced from clinicaltrials.gov