ArrhythmiaS in Pulmonary arterIal hypeRtEnsion and Right Heart Failure Assessed by Continuous Long-term Cardiac Monitoring
Arrhythmias are considered a prominent phenomenon in pulmonary hypertension (PH) as the disease progresses. According primarily to retrospective studies with up to 24 hours of monitoring, supraventricular tachycardias (SVT) can be found in 8-35% of patients, with significant impact on survival. Furthermore, a few prospective studies to date deploying short-term monitoring (10 minutes-24 hours) have revealed lower heart rate variability (HRV) in patients with pulmonary arterial hypertension (PAH). In ASPIRE arrhythmias and heart rate variability is being assessed via long term monitoring. Currently the the loop-recorder is considered the gold standard for long-term continuous cardiac montoring. A non-invasive continuous monitoring could be of a great benefit for the patients, and could potentially contribute to treatment optimization. The study will assess apple watches as a non-invasive tool compared to to the loop recorder, which is considered as the current gold standard. Additionally, the study seeks to assess apple watches for monitoring as an independent wearable for risk assessment in PH.
• Pulmonary hypertension patients \>18 years of age
‣ Voluntary participation after giving informed verbal and written consent
⁃ Patients naïve to PAH-specific treatments
⁃ Patients on current PAH specific medication independent of duration of therapy
⁃ Patients can be in WHO group 1 classified by one of the following subgroups:
⁃ Idiopathic pulmonary arterial hypertension (IPAH)
⁃ Heritable pulmonary arterial hypertension (HPAH)
⁃ Drugs and toxins
⁃ Associated with (APAH): specifically, connective tissue disease (CTD), HIV infection and congenital heart disease
⁃ Patients with chronic thromboembolic pulmonary hypertension
⁃ Diagnosis of PAH confirmed by right heart catheterization
⁃ WHO/NYHA functional class II to IV symptoms
⁃ 6MWT distances of ≥50 meters and within 15% of each other on 2 consecutive tests preferably performed on different days during Screening.