Bariatric Surgery Evaluation and Assessment of Treatment Efficacy in Heart Failure with Preserved Ejection Fraction - Intervention Trial
The goal of this clinical trial is to evaluate if a bariatric surgery strategy will improve clinical endpoints, cardiac parameters and functional status in patients with obesity (with BMI 32-40 kg/m2) and symptomatic HF with preserved or mildly reduced LVEF in combination with AF, as compared to standard of care. Patients will be randomized to either the Intervention group receiving bariatric surgery including an intensive pre- and postoperative treatment scheme or to the control group receiving standard of care.
• Signs and symptoms of HF according to the Europeans Society of Cardiology guideline;
• Left ventricular ejection fraction ≥40%;
• HFA-PEFF score ≥5 or HFA-PEFF score 2-4 in combination with positive stress test;
• Between 45 and 70 years of age;
• BMI 32-40 kg/m2;
• Paroxysmal or persistent AF with a rhythm control strategy;
• Willing to undergo both treatment strategies;
• Written informed consent.