Effects of Carnosine In Patients With Peripheral Arterial Disease Patients; Randomized Intervention Trial (CIPHER)
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
The purpose of this study is to determine whether carnosine (a food ingredient found in chicken and red meat) supplementation (2 g) for 6 months in participants with non-claudication and claudication peripheral arterial disease (PAD) improves walking ability. Previous studies with heart failure patients have shown that carnosine supplementation increases walking capacity in these patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 80
Healthy Volunteers: f
View:
• Participants between 40-80 years of age.
• White or African American race.
• Literate in English.
• ABI \>0.4-\<0.90, obtained within 6 weeks from enrollment.
• Willing and able to comply with protocol requirements.
• Participant is able to provide informed consent.
Locations
United States
Kentucky
University of Louisville School of Medicine, Department of Medicine, Division of Environmental Medicine
RECRUITING
Louisville
University Surgical Associates, 401 E. Chestnut St, Suite 710
NOT_YET_RECRUITING
Louisville
UofL Physicians - Vascular Surgery Associates, 201 Abraham Flexner Way, Suite 1004
NOT_YET_RECRUITING
Louisville
Contact Information
Primary
Shahid Baba, PhD
shahid.baba@louisville.edu
502-296-7713
Backup
Amit Dwivedi, MD
amit.dwivedi@louisville.edu
502-583-8303
Time Frame
Start Date: 2025-05-20
Estimated Completion Date: 2028-10-01
Participants
Target number of participants: 144
Treatments
No_intervention: Placebo
Cellulose
Experimental: Carnosine
Carnosine 2 g daily for 6 months
Related Therapeutic Areas
Sponsors
Collaborators: National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
Leads: Shahid Baba