Heart Failure Clinical Trials

• Age ≥ 18 years at the time of informed consent.

• BMI ≥ 30.0 kg/m\^2 at the time of randomization.

• HF diagnosed for at least 30 days with New York Heart Association (NYHA) Class II-IV at the time of informed consent.

• Managed with HF standard of care therapies.

• Left ventricular ejection fraction (LVEF) of \> 40% within 12 months from the beginning of screening.

• Elevated NT-proBNP.

• Participants must have at least one of the following:

‣ Structural heart disease within 12 months prior to screening OR

⁃ Documented hospitalization with a primary diagnosis of decompensated HF which required IV loop diuretic treatment \> 30 days and \< 12 months prior to randomization OR

⁃ Evidence of elevated filling pressures within 12 months before randomization.