A Prospective, Cross-sectional, Nationwide Community-based Observational Study to Determine the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions. The WE-CARE-HF-CMR study, conducted in large cities/metropol areas in Germany ( \> 500.000 inhabitants), aims to close this gap by evaluating the feasibility of a mobile, telemedicinemonitored HF-screening approach combining cardiac magnetic resonance imaging (CMR), quality of life assessment and laboratory tests as key elements in asymptomatic patients at risk. WE-CARE-HF-CMR will provide a proposal for a comprehensive, contemporary screening approach for patients at risk to develop HF tailored to the needs of the target population. This will provide important new information on the prevalence of asymptomatic HF in at-risk patients in urban versus rural areas. The results of the study will be compared with the results from the HERZCheck'' trial, which provides data from approximately 4,500 participants in rural areas in Germany and has already been completed (NCT05122793).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 69
Healthy Volunteers: f
View:

⁃ Asymptomatic subjects with:

• chronic diabetes mellitus (known/diagnosed and/or antidiabetic medication and/or elevated HbA1C) and/or

• renal impairment (known/diagnosed CKD and/or in laboratory CKD III° or higher) and/or

• Hypertension (known/diagnosed and/or antihypertensive medication/treatment) and/or

• Hypercholesterolaemia (known/diagnosed and/or antilipid medication/treatment) and/or

• Obesity (known/diagnosed and/or BMI \> 30 (kg/m²)) and/or

• Smoker (known/diagnosed and/or current/previous and/or medication/treatment)

• Age 40-69 years

• female or male or diverse sex

• Ability to provide informed consent

• Provision of Informed Consent

Locations
Other Locations
Germany
Deutsches Herzzentrum der Charité
RECRUITING
Berlin
Contact Information
Primary
Prof. Dr. Sebastian Kelle
sebastian.kelle@dhzc-charite.de
+493045931182
Backup
Dr. Gisela Thiede
gisela.thiede@dhzc-charite.de
+4915209192843
Time Frame
Start Date: 2025-09-13
Estimated Completion Date: 2035-12-31
Participants
Target number of participants: 450
Treatments
Patients at risk of heart failure
asymptomatic individuals, residing in urban areas in Germany, between the age of 40 to 69 years without known HF and at least one established cardiovascular risk factor
Sponsors
Leads: German Heart Institute
Collaborators: AstraZeneca, Medical Statistics, University Medicine of Goettingen

This content was sourced from clinicaltrials.gov