Neuroplastic Changes and Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Upper and Lower Extremity in Chronic Stroke Patients
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of lower extremity in the chronic phase after stroke. It also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age over 18
• Chronic stroke (\>6 months)
• Residual hemiparesis FAC ≥3
Locations
Other Locations
Sweden
Department of Rehabilitation Medicine, Danderyd Hospital, Danderyd, Stockholm 18288
RECRUITING
Stockholm
Contact Information
Primary
Susanne Palmcrantz, PhD, Associate Professor
susanne.palmcrantz@ki.se
004681235000
Time Frame
Start Date: 2025-11
Estimated Completion Date: 2030-12
Participants
Target number of participants: 56
Treatments
Experimental: Contralesional cerebellum iTBS and conventional rehabilitation
The experimental group will receive intermittent theta burst stimulation on the contralesional cerebellum followed by 45 minutes of conventional rehabilitation interventions involving the lower extremity led or instructed by a physiotherapist.
Sham_comparator: Contralesional cerebellum sham-iTBS and conventional rehabilitation
The placebo group will get sham intermittent theta burst stimulation on the contralesional cerebellum followed by 45 minutes of conventional rehabilitation interventions involving the lower extremity led or instructed by a physiotherapist.
Related Therapeutic Areas
Sponsors
Collaborators: Karolinska Institutet
Leads: Danderyd Hospital