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Latest Advances in
Hemoglobinopathy
Overview
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Clinical Trials
Latest Advances
Condition:
Thalassemia
Journal:
Blood advances
Treatment Used:
Luspatercept
Number of Patients:
336
Published —
February 11, 2021
The study researched the use of luspatercept for patients with thalassemia.
Condition:
Sickle Cell Disease
Journal:
Blood advances
Treatment Used:
Allogeneic Stem Cell Transplantation with Omidubicel
Number of Patients:
13
Published —
February 09, 2021
This study tested the safety and efficacy of using allogeneic stem cell transplantation with omidubicel to treat patients with sickle cell disease.
Condition:
Chronically Transfused Patients with Thalassemia
Journal:
Immunohematology
Treatment Used:
Antigen-Matched Red Blood Cell Units
Number of Patients:
24
Published —
February 05, 2021
This study determined the benefits of antigen matched transfusion guided by DNA-based typing in chronically transfused patients with thalassemia (blood disorder).
Condition:
Sickle Cell Disease and Thalassemia
Journal:
Blood advances
Treatment Used:
Stem Cell Transplant or Gene Therapy
Number of Patients:
517
Published —
January 26, 2021
This systematic review evaluated the quality of life in patients with sickle cell disease (SCD) and thalassemia after treatment with hematopoietic stem cell transplant (HSCT) or gene therapy.
Condition:
Thalassemia
Journal:
PloS one
Treatment Used:
Iron Reduction Therapy
Number of Patients:
149
Published —
January 22, 2021
This study tested the safety and efficacy of using iron reduction therapy to treat patients with thalassemia.
Condition:
?-Thalassemia Major
Journal:
Hemoglobin
Treatment Used:
Calcium Channel Blockers(CCBs) in Conjunction with Standard Iron-Chelating Agents
Number of Patients:
210
Published —
January 12, 2021
This review of the literature investigated d the clinical effectiveness of calcium channel blockers (CCBs) in conjunction with chelation therapy for reducing iron overload in patients with thalassemia (blood disorder).
Condition:
Schizophrenia
Journal:
Journal of clinical psychopharmacology
Treatment Used:
Nanocurcumin
Number of Patients:
56
Published —
December 21, 2020
In this study, researchers evaluated the safety and effectiveness of nanocurcumin for the treatment of negative symptoms in patients with schizophrenia.
Condition:
Sickle Cell Disease
Journal:
The New England journal of medicine
Treatment Used:
Post-Transcriptional Genetic Silencing of BCL11A
Number of Patients:
6
Published —
December 07, 2020
This study investigated the use of post-transcriptional genetic silencing of BCL11A in the treatment of patients with sickle cell disease.
Condition:
Sickle Cell Disease (SCD) and ?-Thalassemia
Journal:
The New England journal of medicine
Treatment Used:
CRISPR-Cas9 Gene Editing
Number of Patients:
2
Published —
December 07, 2020
This case report describes the use of CRISPR-Cas9 gene editing in the treatment of patients with transfusion-dependent ?-thalassemia (TDT) and sickle cell disease (SCD).
Condition:
Thalassemia
Journal:
Hematology. American Society of Hematology. Education Program
Treatment Used:
Chronic Transfusion
Number of Patients:
0
Published —
December 04, 2020
This article discusses issues concerning chronic transfusion in patients with thalassemia.
Condition:
Osteonecrosis of the Femoral Head
Journal:
Journal of biological regulators and homeostatic agents
Treatment Used:
Total Hip Replacement
Number of Patients:
12
Published —
December 02, 2020
In this study, researchers evaluated the outcomes of undergoing total hip replacement for the treatment of osteonecrosis of the femoral head in patients with sickle cell disease.
Condition:
Sickle Cell Disease
Journal:
The Lancet. Haematology
Treatment Used:
Hematopoietic Stem Cell Transplantation (HSCT)
Number of Patients:
0
Published —
November 26, 2020
This article discusses the role of hematopoietic stem cell transplantation (HSCT) for sickle cell disease in the era of targeted disease-modifying therapies and gene editing.
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