⁃ Adults: \> 15 years and 6 months

⁃ Pediatrics: ≥ 3 years and ≤ 15 years and 6 months

⁃ Known SS or Sβ0 phenotypes

‣ 1 -Adults: \> 15 years and 6 months /Pediatrics: ≥ 3 years and ≤ 15 years and 6 months 2-Absence of Hemoglobinopathy 3-Follow-up for one of the following conditions (adults): Evaluation of hematological disease excluding hemoglobinopathy, evaluation of prolonged fever or inflammatory syndrome, initial or episodic evaluation of an auto-inflammatory disease or systemic disease, general health deterioration

• Follow-up for one of the following conditions (pediatrics): Suspected precocious puberty, growth delay, or neurodevelopmental disorder

‣ 4-Blood sample planned as part of medical care