CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative pathological or follow-up results as reference standards.
• Persistent hypertension with blood pressure \> 150/100 mmHg, refractory hypertension (blood pressure \>140/90 mmHg with combined use of three types of antihypertensive medications, including diuretics), or with hypokalemia of blood pressure \>140/90 mmHg;
• Refractory hypertension with an aldosterone-to-renin ratio (ARR) ≥ 2.0 (ng/dl)/(mU/L);
• Positive intravenous salt-loading test or captopril test;
• Hypertension and adrenal lesions;
• Patient ≥18 years of age at the time of consent;
• Provided written informed consent authorisation before participating in the study.