Effects of an Energy-restricted Diet on the Expression of the Sirtuin-1 and Leptin Receptor Genes in White Blood Cells, and Cardiometabolic Markers in Individuals With Hypertriglyceridemia: Comparison Between Low and High Weight Loss Responders
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Total RNA is extracted from isolated white blood cells, and cDNA is synthesized from these samples. Subsequently, the expression levels of the SIRT1 and leptin receptor genes are determined through quantitative PCR.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Mild to moderate hypertriglyceridemia (TG=150-500 mg/dL)
• Body mass index (BMI) greater than 25
• Not using fibrates
Locations
Other Locations
Islamic Republic of Iran
Nutrition Clinic located in the Faculty of Nutrition Sciences, Shahid Beheshti University of Medical Sciences
RECRUITING
Tehran
Contact Information
Primary
Fahime Ansarifard, Msc
fahime.ansarifard@gmail.com
+989919857529
Time Frame
Start Date: 2025-06-10
Estimated Completion Date: 2025-10-01
Participants
Target number of participants: 90
Treatments
Other: Low-calorie diet
Low-calorie diet
Related Therapeutic Areas
Sponsors
Leads: Shahid Beheshti University of Medical Sciences