Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• Postpartum women aged 18 years or older
• Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
• Taking Nifedipine 60 mg every 12 hours for blood pressure control
• Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
• English speaking
Locations
United States
Ohio
Cleveland Clinic
RECRUITING
Cleveland
Contact Information
Primary
Amol Malshe, M.D.
malshea@ccf.org
216 903-9646
Time Frame
Start Date: 2026-03-10
Estimated Completion Date: 2029-12-31
Participants
Target number of participants: 200
Treatments
Experimental: Nifedipine and Enalapril
Nifedipine 60mg by mouth every twelve hours plus Enalapril 5mg by mouth every twelve hours
Active_comparator: Nifedipine and Labetalol
Nifedipine 60mg by mouth every twelve hours plus Labetalol 200mg by mouth every twelve hours
Related Therapeutic Areas
Sponsors
Leads: The Cleveland Clinic