Is Thin Endometrial Lining Associated with Senescent Endometrial Cells
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: * Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial biopsy with Pipelle catheter
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 39
Healthy Volunteers: t
View:
• Age 18-39
• BMI - up to 35
• Thin endometrium after OCP use
• Asherman's syndrome
• Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing)
• Women with archived endometrial biopsy samples
Locations
Other Locations
Canada
Trio Fertility
RECRUITING
Toronto
Time Frame
Start Date: 2024-09-11
Estimated Completion Date: 2027-06
Participants
Target number of participants: 100
Treatments
Thin endometrial lining
Patients following long-term use of oral contraceptives with known thin endometrial lining (less than 7mm, confirmed in at least two cycles and unresponsive to estrogen-induced growth).~We will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase.
Asherman's syndrome
Patients with Asherman's syndrome following Dilation and curettage (D\&C). We will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase.
Control
Patients already scheduled to undergo an endometrial biopsy for infertility management.~We will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase. In some cases, we may be able to access archived endometrial samples from women in the control group who agree to participate and who have already had an endometrial biopsy.
Related Therapeutic Areas
Sponsors
Leads: Trio Fertility