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Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress in Men With Altered Semen Parameters: A Randomized Controlled Study

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality. The study will also examine how this dietary intervention affects oxidative stress and whether it is well tolerated. The main questions this study aims to answer are: * Does daily consumption of gazpacho improve semen quality in men with altered semen parameters? * Does this dietary intervention affect levels of oxidative stress in semen? * Is daily gazpacho intake feasible and well tolerated as part of a Mediterranean diet? Researchers will compare a Mediterranean diet plus daily gazpacho intake with a Mediterranean diet alone to determine whether adding gazpacho provides additional benefits for male reproductive health. Participants will: * Follow a standardized Mediterranean diet for 12 weeks * Drink 330 mL of gazpacho every day or follow the diet without gazpacho * Provide semen samples at the start of the study and after 12 weeks * Complete a short diary to record adherence to the dietary intervention * Be followed for up to 18 months to record reproductive outcomes

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• Men aged 18 to 45 years

• Andrological profile including altered semen parameters such as oligozoospermia, asthenozoospermia and/or teratozoospermia (O±A±T)

• No clinical indication for sperm DNA fragmentation testing or advanced sperm selection techniques

• Willingness and ability to comply with the study protocol, including adherence to a standardized Mediterranean diet

• Signed and dated written informed consent form

Locations
Other Locations
Spain
GINEFIV Madrid (IVIRMA Group)
RECRUITING
Madrid
Contact Information
Primary
Pablo Martí Pastor, RN, RDN
pablo.marti@ginefiv.com
+34 669975090
Backup
Julio Gijón de la Santa, Senior Clinical Embryologist
julio.gijon@ginefiv.com
636636799
Time Frame
Start Date: 2026-03-02
Estimated Completion Date: 2029-09-01
Participants
Target number of participants: 80
Treatments
Active_comparator: Standardized Mediterranean Diet Alone (Control)
Participants will follow a standardized Mediterranean diet for a period of 12 weeks. Adherence to the dietary recommendations will be monitored using a self-administered compliance diary and scheduled follow-up phone calls.
Experimental: Gazpacho + Standardized Mediterranean Diet (Intervention)
Participants assigned to the intervention arm will follow a standardized Mediterranean diet for 12 weeks and will additionally consume 330 mL of commercially available gazpacho once daily with a main meal. Adherence to the intervention will be monitored using a self-administered compliance diary and scheduled follow-up phone calls.
Related Therapeutic Areas
Sponsors
Leads: Ginefiv
Collaborators: Instituto Valenciano de Infertilidad, IVI VALENCIA

This content was sourced from clinicaltrials.gov