Molecular Mechanisms for Male Fertility: Can Diet Change Sperm SncRNA and the Reproductive Potential?
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
In this study, patients with infertility treated with IVF at the Center of Reproductive Medicine in Linköping, Sweden, will receive recipes and food according to Nordic dietary guidelines. The purpose is to investigate whether a short diet intervention is sufficient to improve sperm quality and shift the small non-coding RNA profile. In our previous study sperm showed rapid response to diet.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 23
Maximum Age: 56
Healthy Volunteers: f
View:
• Male (biological) partner in infertile couple, scheduled for first IVF treatment
• Mature sperm cells in semen
• Able to speak and read Swedish
• Omnivore
• Will refrain from nicotine and alcohol during intervention
• Sperm sampled provided no more than 3 weeks before intervention start
Locations
Other Locations
Sweden
University Hospital
RECRUITING
Linköping
Contact Information
Primary
Susanne Liffner, M.D, Ph.D.
susanne.liffner@liu.se
+46 (0)101030000
Time Frame
Start Date: 2024-12-26
Estimated Completion Date: 2027-12
Participants
Target number of participants: 100
Treatments
Active_comparator: Diet intervention- Nordic nutrition recommendations
The intervention group will receive groceries with planned recipes during the hormonal treatment period for the woman (11-14 days) before IVF. The meal plan will be according to the Nordic dietary guidelines and individualized to match total energy expenditure.
No_intervention: No diet intervention
No intervention - this group will only receive standard care
Related Therapeutic Areas
Sponsors
Leads: Ostergotland County Council, Sweden