A Randomized Double Blind Controlled Comparison of Oral Dydrogesterone as Luteal Phase Support in Natural Cycle Frozen-thawed Embryo Transfer
Who is this study for? Adult female patients age 18 to 42 with infertility
What treatments are being studied? Dydrogesterone
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support. The hypothesis is that the use of oral dydrogesterone will increase the live birth rate of natural cycle FET.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 42
Healthy Volunteers: f
View:
• Age of women \<43 years at the time of stimulated IVF
• Replacing early cleavage embryos or blastocysts after thawing
Locations
Other Locations
China
Department of Obstetrics and Gynaecology
RECRUITING
Hong Kong
Contact Information
Primary
Ernest HY Ng, MD
nghye@hku.hk
852-28553400
Time Frame
Start Date: 2021-07-01
Estimated Completion Date: 2026-11-30
Participants
Target number of participants: 716
Treatments
Experimental: Dydrogesterone group
Oral dydrogesterone 10mg tds will be given for two weeks from the next day of the LH surge or hCG induced ovulation.
Placebo_comparator: Placebo group
Placebo will be given given for two weeks from the next day of the LH surge or hCG induced ovulation.
Related Therapeutic Areas
Sponsors
Leads: The University of Hong Kong