Bioimpedence and Arterial Function Monitoring at Birth and in Infants: the BAMBI Study

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Observational
SUMMARY

Babies may be born appropriately grown for gestational age (AGA, \>10th centile) or small for gestational age (SGA, \<10th centile). Babies who are SGA and have evidence in utero of vascular compromise using antenatal doppler indices are classified as having fetal growth restriction (FGR). Babies with FGR are at increased risk of cardiovascular disease in adult life. Increased arterial stiffness and intima-media thickness are thought to mediate this risk in adults. It is not known how early in life these changes can be robustly detected. In addition, very little is known generally about how babies' hearts and arteries change in structure and function over the first year of life, whether affected by SGA or not. This study aims to understand if there are differences in cardiac and arterial structure and function between babies born AGA or SGA. Within the group of SGA babies, the study team will investigate whether FGR and maternal pre-eclampsia influence these measurements. The effects gestational age on these parameters will be studied within all groups: half of the babies recruited will be \<32 weeks gestational age (GA), and half will be ≥32 weeks GA. Study participants will have further measurements at 3-6 months of life to assess if cardiac and arterial structure and function change in babies over the first year of life. The study team will use the Vicorder device to measure arterial stiffness, and assess the feasibility of using this device in neonates. The Vicorder will also be used to measure cardiac output. The feasibility and validity of this device for this purpose will be investigated (Vicorder is not validated for cardiac output measurement in infants). Vicorder cardiac output results will be compared to echocardiography and bioimpedence technology (using the NICaS monitor). The study team will use ultrasound for arterial structure measurements of the carotid artery and aorta.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 6 months
Healthy Volunteers: t
View:

• Healthy term infants (including those with SGA+/-FGR) in the postnatal ward

• Term and Preterm infants (including those with SGA+/-FGR) admitted to the neonatal unit

• Written informed parental consent

Locations
Other Locations
United Kingdom
Queen Charlotte's and Chelsea Hospital
RECRUITING
London
St Mary's Hospital
RECRUITING
London
Contact Information
Primary
Jayanta Banerjee, MD (Res), FRCPCH
j.banerjee@imperial.ac.uk
020 3313 7308
Time Frame
Start Date: 2020-12-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 120
Treatments
Appropriately grown for age infants
40 appropriately grown for gestational age (AGA) infants. 20 will be \<32 weeks, and 20 will be ≥32 weeks gestational age at birth.
Small for gestational age infants
40 small for gestational age (SGA) infants. 20 will be \<32 weeks, and 20 will be ≥32 weeks gestational age at birth.
Fetal growth restricted infants
40 fetal growth restricted (FGR) infants. 20 will be \<32 weeks, and 20 will be ≥32 weeks gestational age at birth.
Sponsors
Leads: Imperial College Healthcare NHS Trust

This content was sourced from clinicaltrials.gov