Novel Applications for Sarcoma Assessment

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

This research aims to improve the way of deciding whether a lump in soft tissue such as fat or muscle is a type of cancer called a soft tissue sarcoma, or if it is benign (non-cancerous). To do this the investigators will use routine clinical MRI scans, additional quantitative MRI scans and artificial intelligence. The aims of this research are: To develop AI algorithms that can accurately classify soft tissue masses as benign or malignant using routine and quantitative MR images. To classify malignant soft tissue masses into their pathological grade. Compare different AI models on external, unseen testing sets to determine which offers the best performance. Participants will be asked if they can spend up to a maximum of 10 extra minutes in an MRI scanner so that the extra images can be acquired. A small subset of participants will be invited back so the investigators can check the reproducibility of the images and the AI software.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with a soft tissue mass that are discussed at the sarcoma multi-disciplinary meeting

• Undergoing MRI as part of their standard of care

• Participant is willing and able to give informed consent for participation in the trial.

Locations
Other Locations
United Kingdom
Leeds Teaching Hospitals
RECRUITING
Leeds
Contact Information
Primary
Matthew Marzetti, MSc
m.marzetti@nhs.net
+44 1133 923055
Time Frame
Start Date: 2023-08-09
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 250
Treatments
Original cohort
This cohort will have a maximum of 10 minutes of quantitative MRI sequences added on to the end of the clinical standard MRI scan
Reproducibility cohort
This group will be invited back for a second MRI scan to test reproducibility of quantitative scans and the machine learning algorithms developed to interpret them.
Related Therapeutic Areas
Sponsors
Leads: The Leeds Teaching Hospitals NHS Trust

This content was sourced from clinicaltrials.gov