Lennox-Gastaut Syndrome (LGS)Symptoms, Doctors, Treatments, Advances & More
Learn About Lennox-Gastaut Syndrome (LGS)
Lennox-Gastaut syndrome is a severe condition characterized by repeated seizures (epilepsy) that begin early in life. Affected individuals have multiple types of seizures, developmental delays, and particular patterns of brain activity measured by a test called an electroencephalogram (EEG). An EEG shows a slow spike-and-wave pattern during wakefulness and generalized paroxysmal fast activity during sleep.
Lennox-Gastaut syndrome can have many different causes. The disorder likely has a genetic component, although the specific genetic factors are not well understood.
Lennox-Gastaut syndrome affects an estimated 1 to 2 per million people worldwide. This condition accounts for 3 to 4 percent of cases of epilepsy in children and 1 to 2 percent of cases in adults. For unknown reasons, it appears to be more common in males than in females.
Most cases of Lennox-Gastaut syndrome are sporadic, which means they occur in people with no history of the disorder in their family. When Lennox-Gastaut syndrome is associated with a genetic change, the variant is usually not inherited but occurs as a random (de novo) event during the formation of reproductive cells (eggs or sperm) in an affected person's parent or during early embryonic development. However, 3 to 30 percent of people with this condition have a family history of some type of epilepsy, indicating that inherited genetic factors may play a role in some cases of Lennox-Gastaut syndrome.
Banner - University Medical Center Phoenix - Banner - University Medicine Institutes 755
I enjoy patient advocate group activities as well as swimming and hiking. Dr. Chung is rated as an Elite provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Seizures, Epilepsy, Lennox-Gastaut Syndrome (LGS), and Generalized Tonic-Clonic Seizure. Dr. Chung is board certified in American Board Of Psychiatry & Neurology and American Board Of Clinical Neurophysiology. Dr. Chung is currently accepting new patients.
Young Adult Institute Inc
Steven Wolf is a Pediatrics provider practicing medicine in New York, New York. Dr. Wolf is rated as an Elite provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Epilepsy, Lennox-Gastaut Syndrome (LGS), Seizures, Thrombectomy, and Deep Brain Stimulation.
Children's Hospital Colorado
Kelly Knupp is a Pediatrics provider practicing medicine in Aurora, Colorado. She has been practicing medicine for over 29 years. Dr. Knupp is rated as an Elite provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). She is also highly rated in 16 other conditions, according to our data. Her clinical expertise encompasses West Syndrome, Myoclonic Epilepsy, Spasmus Nutans, and Dravet Syndrome. Dr. Knupp is board certified in American Board Of Psychiatry And Neurology and American Board Of Psychiatry And Neurology. Dr. Knupp is currently accepting new patients.
Summary: Cannabidiol oral solution (CBD-OS) is approved in the US for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or Tuberous sclerosis complex (TSC) in patients 1 year of age and older. This study will assess the efficacy and safety of CBD-OS in participants aged 12 to 75 years for the treatment of focal-onset seizures (FOS).
Summary: This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole HCL (EPX-100) as adjunctive therapy in children and adult participants with Lennox-Gastaut syndrome (LGS).
Published Date: May 03, 2023
Published By: National Institutes of Health