Lennox-Gastaut Syndrome (LGS) Overview
Learn About Lennox-Gastaut Syndrome (LGS)
Lennox-Gastaut syndrome is a severe condition characterized by repeated seizures (epilepsy) that begin early in life. Affected individuals have multiple types of seizures, developmental delays, and particular patterns of brain activity measured by a test called an electroencephalogram (EEG). An EEG shows a slow spike-and-wave pattern during wakefulness and generalized paroxysmal fast activity during sleep.
Lennox-Gastaut syndrome can have many different causes. The disorder likely has a genetic component, although the specific genetic factors are not well understood.
Lennox-Gastaut syndrome affects an estimated 1 to 2 per million people worldwide. This condition accounts for 3 to 4 percent of cases of epilepsy in children and 1 to 2 percent of cases in adults. For unknown reasons, it appears to be more common in males than in females.
Most cases of Lennox-Gastaut syndrome are sporadic, which means they occur in people with no history of the disorder in their family. When Lennox-Gastaut syndrome is associated with a genetic change, the variant is usually not inherited but occurs as a random (de novo) event during the formation of reproductive cells (eggs or sperm) in an affected person's parent or during early embryonic development. However, 3 to 30 percent of people with this condition have a family history of some type of epilepsy, indicating that inherited genetic factors may play a role in some cases of Lennox-Gastaut syndrome.
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Joseph Sullivan is a Pediatric Neurologist and a Pediatrics provider in San Francisco, California. Dr. Sullivan and is rated as an Elite provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). His top areas of expertise are Myoclonic Epilepsy, Dravet Syndrome, Epilepsy with Myoclonic-Atonic Seizures, and Epilepsy.
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Robert Knowlton is a Neurologist in San Francisco, California. Dr. Knowlton and is rated as an Experienced provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). His top areas of expertise are Seizures, Epilepsy, Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE), Generalized Tonic-Clonic Seizure, and Deep Brain Stimulation.
Raman Sankar is a Pediatrics specialist and a Neurologist in Los Angeles, California. Dr. Sankar and is rated as a Distinguished provider by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). His top areas of expertise are West Syndrome, Epilepsy, Spasmus Nutans, Seizures, and Deep Brain Stimulation.
Summary: This is a prospective, observational study on approximately 70-100 Real World participants affected by LGS, DS, or TSC treated with Epidyolex® as prescribed in the summary of product characteristics. The eligible participants are expected to participate in the study for a duration of 52 weeks of treatment.
Summary: The study is a pilot, open-label, study to test whether BMB-101 is safe and effective in reducing the frequency of seizures in subjects with Absence Epilepsy including Epilepsy with Eyelid Myoclonia (also called Jeavons Syndrome) as well as Developmental Epileptic Encephalopathies such as Dravet and Lennox Gastaut. The study will last up to 6 months. There will be a 1 month screening period, then ...
Published Date: May 03, 2023
Published By: National Institutes of Health