Lennox-Gastaut Syndrome (LGS) Latest Advances

Ultra-rare biallelic THAP12 variants cause loss of function and underlie severe epileptic encephalopathy.

Journal: medRxiv : the preprint server for health sciences

Published: March 13, 2026

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Journal: Journal of the neurological sciences

Published: February 27, 2026

Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy.

Journal: Epilepsy currents

Published: February 23, 2026

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience.

Journal: Neurology and therapy

Published: February 13, 2026

Short-term vigabatrin is safe and effective in Lennox-Gastaut syndrome.

Journal: Journal of the neurological sciences

Published: February 05, 2026

Biallelic RNU2-2-related neurodevelopmental disorder presenting as Lennox-Gastaut syndrome.

Journal: Acta neurologica Belgica

Published: February 05, 2026

Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives.

Journal: Seizure

Published: January 30, 2026

Highly Purified Cannabidiol Treatment Outcomes in Pediatric Patients with Highly Refractory Epilepsy at a Tertiary Center.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Published: January 30, 2026

Urgent completion corpus callosotomy for severe behavioral deterioration associated with seizure exacerbation in adult Lennox-Gastaut syndrome: A clinical vignette.

Journal: Epileptic disorders : international epilepsy journal with videotape

Published: January 29, 2026

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Journal: Journal of the neurological sciences

Published: January 27, 2026

Comment on "safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Journal: Journal of the neurological sciences

Published: January 22, 2026

Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses.

Journal: Epilepsy & behavior : E&B

Published: January 19, 2026

Lennox-Gastaut Syndrome (LGS) Latest Advances

Find the Latest Research About Lennox-Gastaut Syndrome (LGS)

Ultra-rare biallelic THAP12 variants cause loss of function and underlie severe epileptic encephalopathy.

Ultra-rare biallelic THAP12 variants cause loss of function and underlie severe epileptic encephalopathy.

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy.

Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy.

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience.

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience.

Short-term vigabatrin is safe and effective in Lennox-Gastaut syndrome.

Short-term vigabatrin is safe and effective in Lennox-Gastaut syndrome.

Biallelic RNU2-2-related neurodevelopmental disorder presenting as Lennox-Gastaut syndrome.

Biallelic RNU2-2-related neurodevelopmental disorder presenting as Lennox-Gastaut syndrome.

Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives.

Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives.

Highly Purified Cannabidiol Treatment Outcomes in Pediatric Patients with Highly Refractory Epilepsy at a Tertiary Center.

Highly Purified Cannabidiol Treatment Outcomes in Pediatric Patients with Highly Refractory Epilepsy at a Tertiary Center.

Urgent completion corpus callosotomy for severe behavioral deterioration associated with seizure exacerbation in adult Lennox-Gastaut syndrome: A clinical vignette.

Urgent completion corpus callosotomy for severe behavioral deterioration associated with seizure exacerbation in adult Lennox-Gastaut syndrome: A clinical vignette.

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Comment on "safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Comment on "safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses.

Effectiveness and safety of perampanel in patients with lennox-gastaut syndrome: a single-arm meta-analysis with meta-regression and sensitivity analyses.