Lennox-Gastaut Syndrome (LGS) Latest Advances

Find the Latest Research About Lennox-Gastaut Syndrome (LGS)

Last Updated: 06/30/2026

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Found 1910 publications

Unmasking Complex Chromosomal Rearrangement Impacting CHD2 by Genome Sequencing and Optical Genome Mapping in Developmental and Epileptic Encephalopathy-DEE94.

Unmasking Complex Chromosomal Rearrangement Impacting CHD2 by Genome Sequencing and Optical Genome Mapping in Developmental and Epileptic Encephalopathy-DEE94.

Journal: Neuropediatrics

Published: May 08, 2026

Compounded Complexity: The Impact of Social Determinants of Health on a Child With Cerebral Palsy and Lennox-Gastaut Syndrome.

Compounded Complexity: The Impact of Social Determinants of Health on a Child With Cerebral Palsy and Lennox-Gastaut Syndrome.

Journal: Cureus

Published: May 04, 2026

Reversible Pulmonary Arterial Hypertension Due to Fenfluramine in a Young Child: A Case Report.

Reversible Pulmonary Arterial Hypertension Due to Fenfluramine in a Young Child: A Case Report.

Journal: Cureus

Published: May 01, 2026

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox-Gastaut syndrome.

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox-Gastaut syndrome.

Journal: Epilepsia open

Published: March 19, 2026

Pediatric epilepsy surgery: Global survey of referral and presurgical evaluation practices.

Pediatric epilepsy surgery: Global survey of referral and presurgical evaluation practices.

Journal: Epilepsia

Published: March 13, 2026

Ultra-rare biallelic THAP12 variants cause loss of function and underlie severe epileptic encephalopathy.

Ultra-rare biallelic THAP12 variants cause loss of function and underlie severe epileptic encephalopathy.

Journal: medRxiv : the preprint server for health sciences

Published: March 13, 2026

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real-world clinical-practice study.

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real-world clinical-practice study.

Journal: Epilepsia

Published: March 11, 2026

Fenfluramine in developmental and epileptic encephalopathies: An age- and syndrome-stratified systematic review and meta-analysis.

Fenfluramine in developmental and epileptic encephalopathies: An age- and syndrome-stratified systematic review and meta-analysis.

Journal: Seizure

Published: March 11, 2026

Seizure outcomes after thalamic deep brain stimulation in drug-resistant epilepsy: How electrode location, device platform, and epilepsy subtype drive response-A systematic review with pooled analysis.

Seizure outcomes after thalamic deep brain stimulation in drug-resistant epilepsy: How electrode location, device platform, and epilepsy subtype drive response-A systematic review with pooled analysis.

Journal: Epileptic disorders : international epilepsy journal with videotape

Published: March 10, 2026

Adjunctive Cannabidiol for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis of Randomized Trials Across Syndromes, Formulations, and Dose Ranges.

Adjunctive Cannabidiol for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis of Randomized Trials Across Syndromes, Formulations, and Dose Ranges.

Journal: Therapeutics and clinical risk management

Published: March 02, 2026

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Comment on "Safety and efficacy of vigabatrin add on compared to placebo in Lennox-Gastaut syndrome (LennoVig): A single center randomized double-blind placebo-controlled trial".

Journal: Journal of the neurological sciences

Published: February 27, 2026

Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.

Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.

Journal: Epilepsia open

Published: February 25, 2026

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Last Updated: 06/30/2026