Lennox-Gastaut syndrome is a severe condition characterized by recurrent seizures (epilepsy) that begin early in life. Affected individuals have multiple types of seizures, a particular pattern of brain activity (called slow spike-and-wave) measured by a test called an electroencephalogram (EEG), and impaired mental abilities.
Lennox-Gastaut syndrome can have many different causes. The disorder likely has a genetic component, although the specific genetic factors are not well understood.
Lennox-Gastaut syndrome affects an estimated 1 to 2 per million people. This condition accounts for less than 5 percent of all cases of childhood epilepsy. For unknown reasons, it appears to be more common in males than in females.
Most cases of Lennox-Gastaut syndrome are sporadic, which means they occur in people with no history of the disorder in their family. When Lennox-Gastaut syndrome is associated with a genetic change, the variant is usually not inherited but occurs as a random (de novo) event during the formation of reproductive cells (eggs or sperm) in an affected person's parent or in early embryonic development. However, 3 to 30 percent of people with this condition have a family history of some type of epilepsy, indicating that inherited genetic factors may play a role in some cases of Lennox-Gastaut syndrome.
Orrin Devinsky is a Neurologist and a General Surgeon in New York, New York. Devinsky has been practicing medicine for over 41 years and is rated as an Elite expert by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). He is also highly rated in 31 other conditions, according to our data. His top areas of expertise are Dravet Syndrome, Epilepsy, Seizures, Myoclonic Epilepsy, and Deep Brain Stimulation. Devinsky is currently accepting new patients.
John Archer practices in Heidelberg, Australia. Archer is rated as an Elite expert by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). He is also highly rated in 5 other conditions, according to our data. His top areas of expertise are Lennox-Gastaut Syndrome (LGS), Epilepsy, Seizures, Absence Seizure, and Deep Brain Stimulation.
Georgia Montouris is a Neurologist in Weymouth, Massachusetts. Montouris has been practicing medicine for over 48 years and is rated as an Elite expert by MediFind in the treatment of Lennox-Gastaut Syndrome (LGS). She is also highly rated in 17 other conditions, according to our data. Her top areas of expertise are Lennox-Gastaut Syndrome (LGS), Seizures, Epilepsy, and Generalized Tonic-Clonic Seizure. Montouris is currently accepting new patients.
Summary: This study will monitor for potential chronic liver injury and liver fibrosis, in participants treated with cannabidiol oral solution.
Summary: The aims of the study are: to learn if soticlestat, when given as add-on therapy, reduces the number of major motor drop seizures in children, teenagers, and adults with Lennox-Gastaut Syndrome. to assess the safety profile of soticlestat when given in combination with other therapies. Participants will receive their standard antiseizure therapy, plus either tablets of soticlestat or placebo. A pl...
Published Date: September 14, 2022Published By: National Institutes of Health