Supportive Transfusion Program for Patients With Hematologic Malignancies: A Cluster Randomized Trial

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This research study is evaluating whether a new care delivery program that provides access to home blood transfusions in hospice (i.e, HEME-Hospice) compared to regular standard of care improves quality of life, mood, and end-of-life health care utilization for patients with hematologic malignancies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosis of a relapsed/refractory hematologic malignancy

• Age ≥ 18 years

• Receipt of primary oncologic care at DFCI (at least 2 outpatient visits in 12 months prior to enrollment)

• Has received at least one red blood cell (RBC) or platelet transfusion since blood cancer diagnosis in the clinic or hospital setting without a severe transfusion reaction

• Patient resides within catchment served by Care Dimensions Hospice

• Physician-estimated prognosis of six months or less

• Identified informal caregiver of enrolled patient with hematologic malignancy

• Age ≥ 18 years

Locations
United States
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Dana-Farber Cancer Institute
RECRUITING
Boston
Contact Information
Primary
Oreofe Odejide, MD, MPH
Oreofe_Odejide@dfci.harvard.edu
617-632-6864
Backup
Sunny Rosenthal, MPH
sjrosenthal@mgb.org
857-215-2820
Time Frame
Start Date: 2025-09-10
Estimated Completion Date: 2029-05-31
Participants
Target number of participants: 700
Treatments
Experimental: Arm 1: Access to home blood transfusions while enrolled in hospice (HEME-Hospice care)
Participants assigned to access to HEME-Hospice care who enroll in hospice will have at least once weekly assessment of symptoms of anemia and thrombocytopenia by the study team and will receive transfusions at home as indicated. Individualized care appointments with hospice care team providers, and frequency of visits are determined by individual participant need.
No_intervention: Arm 2: Usual Care
Participants assigned to usual care will receive standard oncology care delivered by the hematologic oncologists. Participants will have access to regular/standard hospice care if they elect to enroll in hospice.
Sponsors
Leads: Dana-Farber Cancer Institute
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov