MaximALL More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Healthy Volunteers: t
View:
• no cancer diagnosis
• no lung diseases
• no vascular diseases
• No subjective reduction in physical performance
• age \>/= 18 years
• Completed therapy for ALL
• age \>/= 3 years
• Completed therapy for lymphoma
• age \>/= 3 years
Locations
Other Locations
Germany
Department of Pediatrics and Adolescent Medicine
RECRUITING
Erlangen
Contact Information
Primary
Axel Karow, PD. Dr. med.
axel.karow@uk-erlangen.de
09131 8533118
Backup
Ferdinand Knieling, Prof. Dr. med.
ferdinand.knieling@uk-erlangen.de
09131 8533118
Time Frame
Start Date: 2026-07-14
Estimated Completion Date: 2028-10-31
Participants
Target number of participants: 180
Treatments
Other: Control Group
Healthy individuals with no previous cancer diagnosis. Volunteers will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) is performed.
Other: Survivors of leukemia
Survivors of treatment for acute lymphatic leukemia in childhood or adolescence. Participants will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) and multispectral optoacoustic tomography (MSOT) for Peripheral artery disease (PAD) are performed. compliant data storage). In addition, venous blood samples will be taken for the analysis of molecular biomarkers.
Other: Survivors of lymphoma
Survivors of treatment for lymphoma in childhood or adolescence. Participants will receive physical examination, standardized pulmonary function testing including spirometry and assessment of the diffusing capacity of the lung for carbon monoxide (DLCO) using a single-breath technique and MRI on a low field system (Lung and heart). Furthermore, cardiopulmonary testing (spiroergometry and echocardiography) and multispectral optoacoustic tomography (MSOT) for Peripheral artery disease (PAD) are performed. compliant data storage). In addition, venous blood samples will be taken for the analysis of molecular biomarkers.
Related Therapeutic Areas
Sponsors
Leads: University of Erlangen-Nürnberg Medical School