Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Status: Recruiting
Location: See all (30) locations...
Study Type: Observational
SUMMARY

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a stroke is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥18 years

• Admitted to the hospital with a diagnosis of acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), or aneurysmal subarachnoid hemorrhage (aSAH)

• Radiographic confirmatory evidence of: (1) AIS (based on a focal area of restricted diffusion on MRI), (2) non-traumatic ICH (based on evidence of acute parenchymal hemorrhage CT or brain MRI) or (3) non-traumatic acute aSAH (based on evidence of subarachnoid hemorrhage on CT or MRI and evidence of aneurysm on CT angiography, MR angiography, or conventional catheter-based angiography)

• Able to complete baseline visit in person or by phone within 6 weeks of stroke onset

• Able to provide informed consent by self or proxy

• Fluent in English or Spanish prior to stroke onset

Locations
United States
Arizona
Barrow Neurological Institute
RECRUITING
Phoenix
California
Cedars Sinai Medical Center
RECRUITING
Los Angeles
Kaiser Permanente Los Angeles Medical Center
RECRUITING
Los Angeles
University of California Los Angeles
RECRUITING
Los Angeles
University of California San Diego
RECRUITING
San Diego
Colorado
University of Colorado
RECRUITING
Denver
Florida
Mayo Clinic
RECRUITING
Jacksonville
University of Miami Health System
RECRUITING
Miami
Iowa
University of Iowa
ACTIVE_NOT_RECRUITING
Iowa City
Illinois
The University of Chicago Medical Center
RECRUITING
Chicago
Indiana
Indiana University
RECRUITING
Indianapolis
Massachusetts
Boston Medical Center
RECRUITING
Boston
Massachusetts General Hospital
RECRUITING
Boston
Maryland
University of Maryland Medical Center
RECRUITING
Baltimore
Michigan
University of Michigan
ACTIVE_NOT_RECRUITING
Ann Arbor
Minnesota
University of Minnesota Health
RECRUITING
Minneapolis
Mayo Clinic
RECRUITING
Rochester
Mississippi
University of Mississippi Medical Center
RECRUITING
Jackson
North Carolina
Duke University Medical Center
RECRUITING
Durham
Wake Forest Baptist Health
ACTIVE_NOT_RECRUITING
Winston-salem
New York
Montefiore Medical Center
RECRUITING
The Bronx
Ohio
University of Cincinnati
RECRUITING
Cincinnati
Pennsylvania
The Hospital of the University of Pennsylvania
RECRUITING
Philadelphia
Tennessee
Methodist University Hospital
RECRUITING
Memphis
Texas
Houston Methodist Research Institute
RECRUITING
Houston
UTHealth
RECRUITING
Houston
University of Texas Health Science Center at San Antonio
RECRUITING
San Antonio
Utah
University of Utah
RECRUITING
Salt Lake City
Virginia
University of Virginia
RECRUITING
Charlottesville
Washington
University of Washington, Harborview Medical Center
RECRUITING
Seattle
Contact Information
Primary
James Meschia, MD
meschia.james@mayo.edu
904-953-6515
Time Frame
Start Date: 2021-03-05
Estimated Completion Date: 2025-11-30
Participants
Target number of participants: 8000
Sponsors
Leads: Massachusetts General Hospital
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)

This content was sourced from clinicaltrials.gov