Characterization of the Genomic Risk Underlying Retroperitoneal Liposarcoma

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Adult patients (age ≥18 years).

• Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection

• Will be undergoing surgical resection for treatment of primary or recurrent disease

• Have provided informed consent to participate in this study

Locations
United States
Pennsylvania
Fox Chase Cancer Center
RECRUITING
Philadelphia
Contact Information
Primary
Anthony Villano, MD
anthony.villano@fccc.edu
215-728-3686
Time Frame
Start Date: 2022-03-07
Estimated Completion Date: 2027-08-01
Participants
Target number of participants: 50
Treatments
Cohort 1
The entire study is a singular cohort of patients with retroperitoneal liposarcoma (index or recurrent) who undergo surgical resection of their tumor.
Sponsors
Leads: Fox Chase Cancer Center

This content was sourced from clinicaltrials.gov

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